← BioTransfer GEO Dataset Finder
GEO series

RNA-seq of Mouse Spinal Cord after Lateral Compression Spinal Cord Injury followed by Delayed Atorvastatin or Vehicle Treatment [Bulk RNA-seq of mice spinal cords]

GSE271662 Mus musculus (mouse) RNA-seq (gene expression) 16 samples Submitted 2025/01/05 Platform GPL24247
At a glance

RNA-seq (gene expression) · mouse · 16 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Mus musculus (mouse)
Samples
16 samples: 7 × SCI plus Atorvastatin Spinal Cord Tissue, vs 7 × SCI plus Vehicle Spinal Cord Tissue, vs 2 × Uninjured No-treatment Control Spinal Cord Tissue,Groups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Delayed atorvastatin delivery promotes recovery after experimental spinal cord injuryNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
Summary (written by the submitters)
This dataset supports a study investigating the effects of delayed atorvastatin treatment on gene expression and functional recovery in a chronic mouse model of spinal cord injury (SCI). Twelve-week-old female C57BL/6 mice were subjected to moderate 0.25 mm lateral compression SCI and after two weeks, were treated with atorvastatin (10 mg/kg) or a vehicle control daily for four weeks.
Read the full summary ↓
Bulk RNA sequencing of spinal cord tissues at six weeks post-injury revealed broad alterations to gene expression due to SCI (DEGs common to both treatments and unique to each) and a smaller set of alterations due uniquely to atorvastatin treatment. Atorvastatin treatment specifically activated gene programs associated with axon guidance and fatty acid transport, which may contribute to the enhanced sensorimotor recovery. This RNA-seq dataset offers insights into the molecular underpinnings by which atorvastatin enhances sensorimotor recovery and modulates gene expression post-SCI.
Published in
Delayed atorvastatin delivery promotes recovery after experimental spinal cord injury
Buchl SC, Kim HN, Hur B et al. · Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2025 · PMID 39755500 · doi:10.1016/j.neurot.2024.e00517
This dataset
Open GSE271662 in finder → Find more mouse RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE271662_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1132719 and SRA study SRP518382. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 39755500) ↗
Study design
7 × SCI plus Atorvastatin Spinal Cord Tissue, vs 7 × SCI plus Vehicle Spinal Cord Tissue, vs 2 × Uninjured No-treatment Control Spinal Cord Tissue,

Supports a between-group comparison across 16 samples.

How we read this: 3 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
Datasets on a similar topic

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.