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Dynamics of γδ TCR repertoire during the de-differentiation and treatment course of thyroid cancer [mouse scRNA]

GSE224720 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2024/12/31 Platform GPL21493
Summary
Although the de-differentiation process of thyroid cancer has been studied, it remains unclear how T cell antigen receptor (TCR) dynamically changes during the cancer progression and treatment. Here we characterized the γδ TCR repertoire along the de-differentiation of thyroid cancers cross-sectionally and investigated the longitudinal changes of TCR components over time in thyroid cancer patients receiving different treatment. We found that better differentiated status was significantly related to greater diversity and lower clonality. Expanded TCRs show enhanced convergent recombination and improved antigen-driven anti-tumor immune responses. The longitudinal study suggested that post-radiotherapeutic immunotherapy led to favorable clinical outcome, which was attributed to the appearance and expansion of neo clonotypes and was validated by scRNA-seq data and murine model experiment. These findings provided a novel understanding in the progression of thyroid cancer and highlighted the role of γδ T cells in anti-tumor immunity.
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Also filed as BioProject PRJNA934485 and SRA study SRP424203. Searching any of these in the dataset finder brings you back here.

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