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Hepatocyte-macrophage crosstalk via the PGRN-EGFR axis modulates ADAR1-mediated immunity in the liver -bulk RNA-seq

GSE225175 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/05/28 Platform GPL21273
Summary
ADAR1 is thought to be an immune suppressor maintaining self-tolerance to endogenous nucleic acids. Lack of ADAR1 results in MDA5 (Ifih1) activation and MDA5 deletion rescues ADAR1 null embryonic lethality. We generated liver specific ADAR1; MDA5 double KO mice and performed high throughput sequencing to investigate hepatic inflammation in these mice. Bulk RNA was sequenced on the HiSeq X platform. Over 100 million pairs of mappable reads for each sample were obtained.
Published in
Hepatocyte-macrophage crosstalk via the PGRN-EGFR axis modulates ADAR1-mediated immunity in the liver
Gan WL, Ren X, Ng VHE et al. · Cell reports 2024 · PMID 38935501 · doi:10.1016/j.celrep.2024.114400
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Also filed as BioProject PRJNA934291 and SRA study SRP422259. Searching any of these in the dataset finder brings you back here.

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