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REV-ERBα regulates regulatory T cell function in inflammatory bowel disease [RNA-seq]

GSE225200 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/11/10 Platform GPL24247
Summary
Colonic Rorgt+Foxp3+ Treg cells are critical to maintain intestinal homeostasis and prevent inflammatory bowel diseases by suppressing exuberant innate and adaptative immune responses. In this study, In this study, we found that REV-ERBa was highly expressed in colonic RORgt+Foxp3+ Treg cells and essential for their differentiation and function. Deletion of REV-ERB in Treg cells lead to diminished colonic RORgt+Foxp3+ Treg cell populations even at steady state, and render mice more susceptible to TNBS and/or oxazolone-induced colitis. As a transcriptional repressor, REV-ERBa can directly repress the expression of pro-inflammatory cytokines IL-17a and IL-17f, and promote RORgt expression through Bhlhe40-c-maf axis in RORgt+Foxp3+ Treg cells. Furthermore, REV-ERB also orchestrate RORgt genome-wide distributions and co-regulate core signature genes in RORgt+Foxp3+ Treg cells, including IL-10, CTLA-4, Icos, c-maf.  
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Direct links to NCBI, no account and no request form: the whole study as GSE225200_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA934504 and SRA study SRP422549. Searching any of these in the dataset finder brings you back here.

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