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Endothelial LATS2 is a suppressor of bone marrow fibrosis

GSE225429 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2024/06/03 Platform GPL19057
Summary
The skeletal system vasculature and specialized capillary subtypes regulate crucial elements of bone growth and regeneration. However, little is known about endothelial cell (EC) activation and plasticity during bone remodeling. Here, we demonstrate that the inactivation of the gene encoding Hippo kinase large tumor suppressor kinase 2 (Lats2) in ECs results in the development of a vascular defect in the metaphysis, which favours accumulation of hypertrophic chondrocytes and induces bone marrow fibrosis in the bone.
Published in
Endothelial LATS2 is a suppressor of bone marrow fibrosis
Sivaraj KK, Majev PG, Dharmalingam B et al. · Nature cardiovascular research 2024 · PMID 39155965 · doi:10.1038/s44161-024-00508-x
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Also filed as BioProject PRJNA935694 and SRA study SRP422999. Searching any of these in the dataset finder brings you back here.

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