Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy
RNA-seq (gene expression) · mouse · 21 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 21 samples: 6 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathyActa neuropathologica communications · 2023
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE226093_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA938486 and SRA study SRP424480. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 21 samples.
How we read this: 6 replicated groups read from 21 sample titles; they account for 21 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7063543 E2H_1 E2H
- GSM7063544 E2H_2 E2H
- GSM7063545 E2H_3 E2H
- GSM7063546 E3H_1 E3H
- GSM7063547 E3H_2 E3H
- GSM7063548 E3H_3 E3H
- GSM7063549 E4H_1 E4H
- GSM7063550 E4H_2 E4H
- GSM7063551 E4H_3 E4H
- GSM7063552 PE2H_1 PE2H
- GSM7063553 PE2H_2 PE2H
- GSM7063554 PE2H_3 PE2H
- GSM7063555 PE2H_4 PE2H
- GSM7063556 PE3H_1 PE3H
- GSM7063557 PE3H_2 PE3H
- GSM7063558 PE3H_3 PE3H
- GSM7063559 PE3H_4 PE3H
- GSM7063560 PE4H_1 PE4H
- GSM7063561 PE4H_2 PE4H
- GSM7063562 PE4H_3 PE4H
- GSM7063563 PE4H_4 PE4H
- GSE307255 HDL-mimetic peptide treatment reverses APOE4-induced transcriptomic and lipidomic alterations in the brain of humanized APOE mice 32 samples shares apoe, humanized
- GSE283736 Transcriptomic changes after orexin receptor antagonism in P301S/E4 mouse model of tauopathy 19 samples shares p301s, tauopathy
- GSE329321 Dihydrotestosterone Supplementation in P301S Female Mice Exacerbates Tauopathy and Microgliosis via the TR4-Trem2 axis 10 samples shares p301s, tauopathy
- GSE286644 Cortical bulk RNA sequencing of APOE-TR mice under calorie restriction and normal diet 69 samples shares apoe
- GSE282066 Accelerated Midlife Endocrine and Bioenergetic Brain Aging in APOE4 Female Mice 59 samples shares apoe
- GSE190186 Cholesterol and matrisome pathways dysregulated in APOE ε4 human microglia and astrocytes [mouseApoe] 44 samples shares apoe
- GSE272446 APOE Protects Against Severe Infection with Mycobacterium tuberculosis by Restraining Production of Neutrophil Extracellular Traps 41 samples shares apoe
- GSE262632 Sex-dependent APOE4 Neutrophil-microglia interactions drive cognitive impairment in Alzheimer's Disease 39 samples shares apoe
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.