Dihydrotestosterone Supplementation in P301S Female Mice Exacerbates Tauopathy and Microgliosis via the TR4-Trem2 axis
RNA-seq (gene expression) · mouse · 10 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 10 samples: 10 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- A non-canonical androgen signaling pathway drives microglial activation and tau pathology in femalesResearch square · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE329321_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1458650 and SRA study SRP695562. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 10 sample titles: 10 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9701730 V10_S10_VOID
- GSM9701731 V11_S11_VOID
- GSM9701732 V4_S4_VOID
- GSM9701733 V5_S5_VOID
- GSM9701734 V9_S9_VOID
- GSM9701735 D1_S18_DHT
- GSM9701736 D2_S19_DHT
- GSM9701737 D3_S20_DHT
- GSM9701738 D5_S22_DHT
- GSM9701739 D6_S23_DHT
- GSE226093 Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy 21 samples shares p301s, tauopathy
- GSE283736 Transcriptomic changes after orexin receptor antagonism in P301S/E4 mouse model of tauopathy 19 samples shares p301s, tauopathy
- GSE298504 Transcriptomic changes underlying the anti-steatotic effects of DHA supplementation in aged obese female mice 8 samples shares supplementation, female
- GSE93180 Tau-P301S sorted cell types 12 samples shares p301s
- GSE285822 snRNA-seq of the hippocampus of Mr1+/+ P301S mice and Mr1-/- P301S mice 8 samples shares p301s
- GSE301033 Transcriptional Response to Non-Steroidal Anti-Inflammatory Drugs and Tryptophan Supplementation 97 samples shares supplementation
- GSE292341 Single cell RNA sequencing of hippocampus and hypothalamus in AD mice with fructose-induced MetS and DHA and NR supplementation 48 samples shares supplementation
- GSE296095 Benefits of Maternal choline supplementation on aged basal forebrain cholinergic neurons in a mouse model of Down syndrome and Alzheimer’s disease 44 samples shares supplementation
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.