Transcriptomic analysis of young aortic tissue in a mouse model of Loeys-Dietz Syndrome Type II harboring a G357W mutation in the Tgfbr2 gene
RNA-seq (gene expression) · mouse · 11 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 11 samples: 6 × Aorta-P11_HET vs 5 × Aorta-P11_WTGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Distinctive Amelogenesis Imperfecta in Loeys-Dietz Syndrome Type IIJournal of dental research · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE226611_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA940806 and SRA study SRP425565. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 11 samples.
How we read this: 2 replicated groups read from 11 sample titles; they account for 11 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7080237 Aorta-P11_WT_replicate 1 Aorta-P11_WT
- GSM7080238 Aorta-P11_WT_replicate 2 Aorta-P11_WT
- GSM7080239 Aorta-P11_WT_replicate 3 Aorta-P11_WT
- GSM7080240 Aorta-P11_WT_replicate 4 Aorta-P11_WT
- GSM7080241 Aorta-P11_WT_replicate 5 Aorta-P11_WT
- GSM7080242 Aorta-P11_HET_replicate 1 Aorta-P11_HET
- GSM7080243 Aorta-P11_HET_replicate 2 Aorta-P11_HET
- GSM7080244 Aorta-P11_HET_replicate 3 Aorta-P11_HET
- GSM7080245 Aorta-P11_HET_replicate 4 Aorta-P11_HET
- GSM7080246 Aorta-P11_HET_replicate 5 Aorta-P11_HET
- GSM7080247 Aorta-P11_HET_replicate 6 Aorta-P11_HET
- GSE284226 Transcriptomic analysis of first molars in a mouse model of Loeys-Dietz Syndrome Type II harboring a G357W mutation in the Tgfbr2 gene 22 samples shares tgfbr2, g357w, loeys-dietz, harboring, mutation, type
- GSE226610 Transcriptomic analysis of enamel organ in a mouse model of Loeys-Dietz Syndrome Type II harboring a G357W mutation in the Tgfbr2 gene 13 samples shares tgfbr2, g357w, loeys-dietz, harboring, mutation, type
- GSE299064 PAM-flexible adenine base editing rescues hearing loss in a humanized MPZL2 mouse model harboring an East Asian founder mutation 9 samples shares harboring, mutation
- GSE255810 Transcriptional profiling of mouse embryonic fibroblasts harboring the Fxn G127V mutation 6 samples shares harboring, mutation
- GSE267204 Intrinsic Gata4 expression sensitizes the aortic root to dilation in a Loeys-Dietz syndrome mouse model 6 samples shares loeys-dietz, aortic
- GSE235638 Chemokine Ligand 2 Expressing Fibroblast Recruitment of Macrophages Enhanced in Loeys-Dietz Syndrome Aortic Root Aneurysm Formation [24wk mouse] 4 samples shares loeys-dietz, aortic
- GSE275791 IDH-mutant glioma arises from glial progenitor cells harboring the initial driver mutation 2 samples shares harboring, mutation
- GSE288084 Chemokine (C-C motif) Ligand 2 Expressing Adventitial Fibroblast Expansion During Loeys-Dietz Syndrome Aortic Aneurysm Formation [8wk mouse] 2 samples shares loeys-dietz, aortic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.