GEO series
Depletion of Apc gene in Cdx2 Gastro ntestinal Cells Facilitates Metastasis of Colorectal Adenocarcinoma Lgr5 Cells to Distant Organs
GSE226641
Mus musculus
Expression profiling by high throughput sequencing
12 samples
2025/03/03
GPL19057
Summary
Caudal type homeobox 2 (CDX2) is a transcription factor expressed in the gastrointestinal (GI) epithelial (IEC) and stromal cells .CDX2 along with APC can regulate Lgr5 intestinal stem cell (ISC) differentiation to control GI tract development or intestinal neoplasia. CDX2 or APC loss function is associated with colorectal cancer (CRC) advance. However, whether APC directly regulates CRC metastasis is not clear. We aim to determine the role of inactive Apc gene in Cdx2 GI cells on Lgr5 ISC metastasis.
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