Immunomodulation by the combination of statin and matrix-bound nanovesicle enhances optic nerve regeneration
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × Retina, ONC, Control vs 3 × Retina, ONC, Fluvastatin + MBV vs 3 × Retina, ONC, Fluvastatin vs 3 × Retina, ONC, MBVGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Immunomodulation by the combination of statin and matrix-bound nanovesicle enhances optic nerve regenerationNPJ Regenerative medicine · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE226780_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA941790 and SRA study SRP426073. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7083714 Retina, ONC, Control_1 Retina, ONC, Control
- GSM7083715 Retina, ONC, Control_2 Retina, ONC, Control
- GSM7083716 Retina, ONC, Control_3 Retina, ONC, Control
- GSM7083717 Retina, ONC, Fluvastatin + MBV_1 Retina, ONC, Fluvastati…
- GSM7083718 Retina, ONC, Fluvastatin + MBV_2 Retina, ONC, Fluvastati…
- GSM7083719 Retina, ONC, Fluvastatin + MBV_3 Retina, ONC, Fluvastati…
- GSM7083720 Retina, ONC, Fluvastatin_1 Retina, ONC, Fluvastatin
- GSM7083721 Retina, ONC, Fluvastatin_2 Retina, ONC, Fluvastatin
- GSM7083722 Retina, ONC, Fluvastatin_3 Retina, ONC, Fluvastatin
- GSM7083723 Retina, ONC, MBV_1 Retina, ONC, MBV
- GSM7083724 Retina, ONC, MBV_2 Retina, ONC, MBV
- GSM7083725 Retina, ONC, MBV_3 Retina, ONC, MBV
- GSE267938 Functional optic tract rewiring via subtype- and target-specific axonal regeneration and presynaptic activity enhancement 256 samples shares regeneration, optic
- GSE267936 Functional Optic Tract Rewiring via Subtype- and Target-specific Axonal Regeneration and Presynaptic Activity Enhancement (bulk RNA-Seq) 40 samples shares regeneration, optic
- GSE324502 Bioinspired, Mitochondria-targeted Single-atom Nanozyme Enhances Bone Regeneration by Reprogramming Stem Cell Energy Metabolism 12 samples shares regeneration, enhances
- GSE329069 Deletion of P311 enhances regeneration in aged skeletal muscle 9 samples shares regeneration, enhances
- GSE297315 Crotonate-activated histone H3K14 crotonylation enhances intestinal regeneration after injury 41 samples shares regeneration, enhances
- GSE284500 Transcriptional profiling of hippocampus from a zQ175 KI mouse model of Huntington's disease treated with either HTT-10150 siRNA targeting full-length HTT or combination of HTT-634 and HTT-486 siRNAs targeting HTT1a 192 samples shares combination
- GSE342349 CT26 multi-tissue RNA-seq under immunotherapy combinations 72 samples shares combination
- GSE276182 NF-κB activation in astrocytes critically affects wound regeneration after traumatic brain injury 51 samples shares regeneration
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.