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Transcriptome data from U2OS cells and hTERT CRISPR clones

GSE226963 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/04/08 Platform GPL18573
Summary
To assess the biological significances of p-hTERT in ALT cells, we used the CRISPR-Cas9 system targeting the hTERT gene and performed RNA-seq to analyze the profile of gene expression in hTERT-CRISPR clones (clone#1 and #2). The subsequent gene ontology (GO) analysis showed enrichment of genes involved in cell cycle process and DNA replication within genes down-regulated in hTERT-CRISPR clones.
Published in
Maintenance of R-loop structures by phosphorylated hTERT preserves genome integrity
Machitani M, Nomura A, Yamashita T et al. · Nature cell biology 2024 · PMID 38806647 · doi:10.1038/s41556-024-01427-6
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Also filed as BioProject PRJNA942325 and SRA study SRP426329. Searching any of these in the dataset finder brings you back here.

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