GEO series
AAV capsid prioritization in machine-perfused normal and steatotic human livers
GSE228000
Homo sapiens
Expression profiling by high throughput sequencing
34 samples
2024/11/12
GPL24676
Summary
Adeno-associated virus (AAV) vectors generated with five different capsids were intravenously injected into human livers undergoing normothermic machine perfusion (NMP). To assess the tropism of the five AAV vectors in the human livers, single-cell suspensions of hepatocytes and non-parenchymal cells (NPCs) were analyzed by single-cell RNA sequencing (scRNAseq). Differentially expressed genes were identified in AAV vector-transduced hepatocytes and unique cell populations.
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Paper (PMID 39881029) ↗
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