AAV capsid prioritization in machine-perfused normal and steatotic human livers
Single-cell RNA-seq · human · 34 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Homo sapiens (human)
- Samples
- 34 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- AAV capsid prioritization in normal and steatotic human livers maintained by machine perfusionNature biotechnology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE228000_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA947648 and SRA study SRP428835. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 34 more — browse all 34 samples with per-sample file links →
- GSE276141 AAV Assembled Capsids Are Produced in Cells Blocked fromFrom Cell Cycle Progression 11 samples shares aav, capsid
- GSE253824 AAV vectors trigger neurotoxic DNA damage responses and STING-dependent inflammation in human CNS cells. 62 samples shares aav
- GSE253820 AAV vectors trigger neurotoxic DNA damage responses and STING-dependent inflammation in human CNS cells [RNA-seq] 40 samples shares aav
- GSE314110 Transcriptional control of hepatocellular carcinoma cells aggressiveness by AAV2/8-mediated delivery of human centenarian-associated SIRT6 N308K/A313S 18 samples shares aav
- GSE226054 Comprehensive mRNA-sequencing-based characterization of three HEK-293 cell lines during an rAAV production process for Gene Therapy Applications 120 samples shares aav
- GSE253821 AAV vectors trigger neurotoxic DNA damage responses and STING-dependent inflammation in human CNS cells [scRNAseq_dataset1] 8 samples shares aav
- GSE253822 AAV vectors trigger neurotoxic DNA damage responses and STING-dependent inflammation in human CNS cells [scRNAseq_dataset2] 8 samples shares aav
- GSE253823 AAV vectors trigger neurotoxic DNA damage responses and STING-dependent inflammation in human CNS cells [scRNAseq_dataset3] 6 samples shares aav
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.