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Effect of epithelial depletion of Wnt10a on gene expression alteration during tooth root furcation development

GSE228411 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/03/16 Platform GPL24247
Summary
In our previous study, the knockout of Wnt10a in dental epithelium resulted in the occurrence of taurodontism and root furcation defects, suggesting that epithelial Wnt10a was a pivotal signal to guide root furcation patterning. Nevertheless, the exact mechanisms within dental epithelium leading root furcation development remained to be deeply elucidated. To explore the downstream molecular alterations caused by epithelial Wnt10a ablation, we conducted RNA-Seq of molar epithelium tissue from furcation region.
Published in
A Wnt10a-Notch signaling axis controls Hertwig's epithelial root sheath cell behaviors during root furcation patterning
Sun K, Yu M, Wang J et al. · International journal of oral science 2024 · PMID 38480698 · doi:10.1038/s41368-024-00288-x
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Also filed as BioProject PRJNA949647 and SRA study SRP429809. Searching any of these in the dataset finder brings you back here.

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