COVID-19 vaccination is associated with attenuation of inflammatory responses during breakthrough disease [Illumina RNA-Seq]
RNA-seq (gene expression) · human · 180 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 180 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Multi-omics analysis reveals COVID-19 vaccine induced attenuation of inflammatory responses during breakthrough diseaseNature communications · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE228839_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA951716 and SRA study SRP430650. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 180 more — browse all 180 samples with per-sample file links →
- GSE228842 COVID-19 vaccination is associated with attenuation of inflammatory responses during breakthrough disease 399 samples shares covid-19, breakthrough, vaccination, attenuation
- GSE261862 Prior vaccination prevents overactivation of innate immune responses during COVID-19 breakthrough infection 16 samples shares covid-19, breakthrough, vaccination
- GSE300696 Identification of reactive CpGs and RNA expression in early COVID-19 through cis-eQTM analysis reflecting disease severity and recovery [RNA-seq] 346 samples shares covid-19, rna-seq
- GSE281864 Detailed delineation of the immune response to COVID-19 mRNA vaccination via high-temporal frequency blood transcriptomics [third] 193 samples shares covid-19, vaccination
- GSE212861 Dynamics of gene expression profiling by RNA-Seq and identification of high-risk patients for severe COVID-19 [RNA-Seq] 93 samples shares covid-19, rna-seq
- GSE243217 Comparative Analysis of Host Responses Between Sepsis and COVID-19: A Prospective Observational Study of Whole Blood Transcriptome (RNA-Seq) 72 samples shares covid-19, rna-seq
- GSE210433 TET2 Mutant Clonal Hematopoiesis Enhances Severity of COVID-19 Related Cytokine Release Syndrome and is Associated with Increased Mortality [scRNA-seq] 34 samples shares covid-19, rna-seq
- GSE208342 Transcriptome and microbiome profile of nasopharyngeal samples among COVID-19 patients with different levels of severity revealed through RNA-seq analysis 20 samples shares covid-19, rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.