Pathogenic mechanism and therapeutic intervention of impaired N7-methylguanosine (m7G) tRNA modification
DNA methylation · mouse · 24 samples
- What it is
- DNA methylationChemical marks on DNA that help switch genes on or off.
- Organism
- Mus musculus (mouse)
- Samples
- 24 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE229612_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for beta-value tables or raw IDAT files among the supplementary files.
Also filed as BioProject PRJNA955159 and SRA study SRP431600. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 6 replicated groups read from 24 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7157547 Input_WT1 Input_WT
- GSM7157548 Input_WT2 Input_WT
- GSM7157549 Input_WT3 Input_WT
- GSM7157550 Input_Homo1 Input_Homo
- GSM7157551 Input_Homo2 Input_Homo
- GSM7157552 Input_Homo3 Input_Homo
- GSM7157553 RNC_WT1 RNC_WT
- GSM7157554 RNC_WT2 RNC_WT
- GSM7157555 RNC_WT3 RNC_WT
- GSM7157556 RNC_Homo1 RNC_Homo
- GSM7157557 RNC_Homo2 RNC_Homo
- GSM7157558 RNC_Homo3 RNC_Homo
- GSM7157568 WT_1 WT
- GSM7157569 WT_2 WT
- GSM7157570 Homo_1 Homo
- GSM7157571 Homo_2 Homo
- GSM7157572 WT_DeM
- GSM7157573 WT_ReD
- GSM7157574 Homo_DeM
- GSM7157575 Homo_ReD
- GSM7166278 WT1, snRNA-seq
- GSM7166279 WT2, snRNA-seq
- GSM7166280 Homo1, snRNA-seq
- GSM7166281 Homo2, snRNA-seq
- GSE305529 METTL3-Driven RNA Modifications: A Key Mechanism and Potential Therapeutic Target in Pancreatic Acinar Cell Carcinoma in Mice [MeRIP] 48 samples shares modification, therapeutic
- GSE308116 Epigenetic modification, as a distinctive therapeutic molecule for Parkinson’s disease gene therapy. 17 samples shares modification, therapeutic
- GSE286704 t6A tRNA modification defines RIG-I mediated anti-tumour [Ribo-seq] immune response 12 samples shares modification, trna
- GSE219240 Unbiased profiling of clinical kinase inhibitors’ effects in activated macrophages using chromatin modifications as high-content readouts 789 samples shares modification
- GSE237916 Regulation of T helper cell differentiation by the interplay between histone modification and chromatin interaction 197 samples shares modification
- GSE307773 Oncogenic MAPK signalling induces epithelial cell state change and therapeutic resistance in vivo [RNA-Seq] 175 samples shares therapeutic
- GSE260851 Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target 161 samples shares therapeutic
- GSE223323 Enterocyte like differentiation defines metabolic gene signatures of CMS3 colorectal cancers and provides therapeutic vulnerability 148 samples shares therapeutic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.