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Impact of USP28 monoallelic deletion in HG3 CLL-derived cells

GSE229756 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2025/05/31 Platform GPL21697
Summary
To investigate the role of USP28 expression in chronic lymphocytic leukemia, we used the CRISPR/Cas9 system to engineer isogenic HG3 cell lines harboring a monoallelic USP28 loss. We then analyzed the transcriptomic profile of these CRISPR/Cas9-generated cell lines by RNA-seq
Published in
NOTCH1 signaling is dysregulated by loss of the deubiquitinase USP28 with del(11q), uncovering USP28 inhibition as novel therapeutic target in CLL
Ehrmann AS, Quijada-Álamo M, Close V et al. · Leukemia 2025 · PMID 40456839 · doi:10.1038/s41375-025-02632-4
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Also filed as BioProject PRJNA955786 and SRA study SRP432721. Searching any of these in the dataset finder brings you back here.

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