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scATAC-seq of mouse 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) induced liver injury model

GSE230091 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 9 samples Submitted 2025/12/31 Platform GPL24247
Summary
Regulatory T cells (Tregs) were shown to protect from cholestatic liver injury. Here we investigate whether amphiregulin (AREG), a ligand for epithelial growth factor receptor (EGFR) which promotes epithelial repair, mediates innate Treg functions in cholangiopathies. Mice were fed with diet containing 0.1 % of the xenobiotic 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) for 14 days to induce sclerosing cholangitis, followed by a 28-day recovery period (without DDC). Liver mononuclear and epithelial cells were enriched and subjected to single-cell sequencing at four time points: baseline, at day 14 of DDC treatment, and following a 14- or 28-day recovery period from 14 days of DDC treatment.
Published in
Bile acids engage the SIPR-STAT3 signaling axis to modulate regulatory T cell responses in fibrosing cholangiopathies
Kudira R, Yang ZF, Osuji I et al. · Journal of hepatology 2025 · PMID 40545044 · doi:10.1016/j.jhep.2025.05.032
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Also filed as BioProject PRJNA957446 and SRA study SRP433447. Searching any of these in the dataset finder brings you back here.

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