Protocadherin 20 maintains intestinal barrier function to protect against Crohn’s disease by targeting ATF6
RNA-seq (gene expression) · human · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 20 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE230113_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA957617 and SRA study SRP433515. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 20 more — browse all 20 samples with per-sample file links →
- GSE280391 Targeting CERT sensitizes AML Cells to FLT3 Inhibitors through activating GRP78-ATF6-CHOP Axis 12 samples shares atf6, targeting
- GSE261040 Epithelial relay of microbial signals coordinates intestinal macrophage supported barrier repair 48 samples shares intestinal, barrier
- GSE284755 Compromised Intestinal Barrier Resilience to Disruption in People with HIV [colon] 30 samples shares intestinal, barrier
- GSE283451 Air-liquid_interface_Caco-2_culture_with_vasointestinal_peptide_ mimicks_ gut_ mucosal_ barrier_ function_ in_ permeability_ and_bacterial infection 17 samples shares intestinal, barrier
- GSE288972 Limosilactobacillus reuteri-derived exopolysaccharides facilitate the repair of intestinal epithelium barrier compromised by chemotherapy exposure 15 samples shares intestinal, barrier
- GSE276369 Comparative Analysis of Caco-2 Cells and Human Jejunal and Duodenal Enteroid-derived Cells in Gel- and Membrane-Based Barrier Models of Intestinal Permeability 13 samples shares intestinal, barrier
- GSE288386 Type 2 calreticulin mutations activate ATF6 to promote BCL-xL-mediated survival in myeloproliferative neoplasms 37 samples shares atf6
- GSE317139 Effect of glucose deprivation and silencing of transcription factors ATF4 and ATF6 on gene expression in human lung adenocarcinoma cell line A549 36 samples shares atf6
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.