Effect of iron exposure on the gene expression profile of human brain vascular pericytes.
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 4 × Control vs 4 × FeCl3 vs 4 × AE2SGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Intracerebral Hemorrhage-Associated Iron Release Leads to Pericyte-Dependent Cerebral Capillary Function DisruptionBiomolecules · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE230184_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA957794 and SRA study SRP433590. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 3 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7191381 Control 1 Control
- GSM7191382 Control 2 Control
- GSM7191383 Control 3 Control
- GSM7191384 Control 4 Control
- GSM7191385 FeCl3 1 FeCl3
- GSM7191386 FeCl3 2 FeCl3
- GSM7191387 FeCl3 3 FeCl3
- GSM7191388 FeCl3 4 FeCl3
- GSM7191389 AE2S 1 AE2S
- GSM7191390 AE2S 2 AE2S
- GSM7191391 AE2S 3 AE2S
- GSM7191392 AE2S 4 AE2S
- GSE319253 Eicosapentaenoic Acid Reprograms Cerebrovascular Metabolism and Impairs Repair after Brain Injury, with Relevance to Chronic Traumatic Encephalopathy [human_brain_OnurE_RNA-seq] 24 samples shares vascular, brain
- GSE291206 Spatial crosstalk modeling of the tumor microenvironment uncovers CCR5-mediated glia-to-glia signaling as a key regulator of brain metastases 18 samples shares brain, iron
- GSE307264 Human myeloid ontogeny drives differentiation potential in the brain environment. 105 samples shares brain, iron
- GSE299072 The brain neurovascular epigenome and its association with dementia 74 samples shares vascular, brain
- GSE322964 Single cell and spatial sequencing analysis of cancer associated fibroblasts in the brain metastasis tumor microenvironment [Multiome] 22 samples shares brain, iron
- GSE291804 Multi-omics analysis of brain metastasis elucidates obesity induced prostaglandin crosstalk in tumor microenvironment restrain CD8T cell expansion 18 samples shares brain, iron
- GSE254569 Gene expression profiles at single-cell level of human post-mortem brain tissue from the orbitofrontal cortex 92 samples shares brain
- GSE277967 Reconstitution of Human Brain Cell Diversity in Organoids via Four Protocols [time-course bulk RNA-seq] 768 samples shares brain
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.