Dorsomorphin (DM) inhibits AMPK, upregulates Wnt and Foxo genes and promotes activation of dormant follicles
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Dorsomorphin inhibits AMPK, upregulates Wnt and Foxo genes and promotes the activation of dormant folliclesCommunications biology · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE230258_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA958140 and SRA study SRP433725. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7210886 Oocytes from primary follicles, DM, rep 1 [LCMRNA1]
- GSM7210887 Oocytes from primary follicles, DM, rep 2 [LCMRNA2]
- GSM7210888 Oocytes from primary follicles, DM, rep 3 [LCMRNA3]
- GSM7210889 Oocytes from primordial follicles, DM, rep 1 [LCMRNA4]
- GSM7210890 Oocytes from primordial follicles, DM, rep 2 [LCMRNA5]
- GSM7210891 Oocytes from primordial follicles, DM, rep 3 [LCMRNA6]
- GSM7210892 Oocytes from primary follicles, sham, rep 1 [LCMRNA7]
- GSM7210893 Oocytes from primary follicles, sham, rep 2 [LCMRNA8]
- GSM7210894 Oocytes from primary follicles, sham, rep 3 [LCMRNA9]
- GSM7210895 Oocytes from primordial follicles, sham, rep 1 [LCMRNA10]
- GSM7210896 Oocytes from primordial follicles, sham, rep 2 [LCMRNA11]
- GSM7210897 Oocytes from primordial follicles, sham, rep 3 [LCMRNA12]
- GSE303657 R-spondin 2 suppresses hepatic steatosis via activation of AMPK-ACC signaling 12 samples shares ampk, activation
- GSE300925 Lyn expression in macrophages promotes TLR activation and restricts proliferation in an isoform-independent manner 48 samples shares activation, promotes
- GSE263688 Ageing promotes metastasis via activation of the integrated stress response 16 samples shares activation, promotes
- GSE327565 Sustained Yap/Taz activation promotes aberrant alveolar epithelial cell differentiation and drives persistent fibrotic remodeling 14 samples shares activation, promotes
- GSE232327 Activation of imprinted gene Pw1 promotes cardiac fibrosis after ischemic injury 41 samples shares activation, promotes
- GSE262131 Increased EZH2 function in regulatory T cells promotes their capacity to suppress autoimmunity by driving effector differentiation prior to activation. 36 samples shares activation, promotes
- GSE305975 Basal level of ATF4 promotes T cell readiness for activation-induced proliferation 29 samples shares activation, promotes
- GSE290022 Mechanism and cellular actions of the potent AMPK inhibitor BAY-3827 64 samples shares ampk
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.