Nuclear lamin A/C phosphorylation by loss of Androgen Receptor is a global determinant of cancer-associated fibroblast activation
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 26 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 26 samples: 26 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Nuclear lamin A/C phosphorylation by loss of androgen receptor leads to cancer-associated fibroblast activationNature communications · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE230508_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA961662 and SRA study SRP434351. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 26 sample titles: 26 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7221803 HDF1_Ctrl_ATAC
- GSM7221804 HDF1_shAR_ATAC
- GSM7225645 HDF1_Ct_inpt
- GSM7225646 HDF1_Ct_LamAC ChIP-Seq
- GSM7225647 HDF1_shAR_inpt
- GSM7225648 HDF1_shAR_LamAC ChIP-Seq
- GSM7412583 HDF1_Lamin_S301D
- GSM7412584 HDF1_Lamin_WT
- GSM7412585 HDF2_Lamin_S301D
- GSM7412586 HDF2_Lamin_WT
- GSM8426810 HDF1_shCtrl_Input
- GSM8426811 HDF1_shCtrl_H3K27Ac ChIP
- GSM8426812 HDF1_shCtrl_LaminA/C ChIP
- GSM8426813 HDF1_shCtrl_pSer301 ChIP
- GSM8426814 HDF1_shAR_Input
- GSM8426815 HDF1_shAR_H3K27Ac ChIP
- GSM8426816 HDF1_shAR_LaminA/C ChIP
- GSM8426817 HDF1_shAR_pSer301 ChIP
- GSM8426818 HDF2_shCtrl_Input
- GSM8426819 HDF2_shCtrl_H3K27Ac ChIP
- GSM8426820 HDF2_shCtrl_LaminA/C ChIP
- GSM8426821 HDF2_shCtrl_pSer301 ChIP
- GSM8426822 HDF2_shAR_Input
- GSM8426823 HDF2_shAR_H3K27Ac ChIP
- GSM8426824 HDF2_shAR_LaminA/C ChIP
- GSM8426825 HDF2_shAR_pSer301 ChIP
- GSE224336 Targeting PDGF signaling of cancer-associated fibroblasts blocks feedback activation of HIF-1α and overcomes chemoresistance in ovarian clear cell carcinoma 15 samples shares cancer-associated, fibroblast, activation
- GSE235244 Senescent cancer-associated fibroblasts in pancreatic adenocarcinoma suppress CD8+ T cell activation and inhibit response to immune checkpoint therapy [hPDAC] 8 samples shares cancer-associated, fibroblast, activation
- GSE275647 Role of Cancer-Associated Fibroblasts in Prognostic Stratification of Advanced-Stage Gastric Cancer through Interacting with Endothelial and Malignant Epithelial Cells [AGC RNA-seq] 216 samples shares cancer-associated, fibroblast
- GSE273882 Arginine Promotes The Activation of Human Lung Fibroblasts Independent of Its Metabolism 52 samples shares fibroblast, activation
- GSE267788 Mechanical stretch induces senescence of alveolar epithelial cells and drives fibroblast activation by paracrine mechanisms 25 samples shares fibroblast, activation
- GSE309392 Cancer-associated fibroblasts promote esophageal carcinogenesis and lung metastasis by CDH11-mediated extracellular matrix environment remodeling [scRNA-Seq] 23 samples shares cancer-associated, fibroblast
- GSE314456 Adipose stromal cell-derived cancer-associated fibroblasts promote pancreatic adenocarcinoma through SFRP4 signaling 20 samples shares cancer-associated, fibroblast
- GSE229047 RNA sequencing data of primary cancer-associated fibroblasts (CAF) isolated from fresh ex vivo germ cell tumor (GCT) patient tissue 19 samples shares cancer-associated, fibroblast
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.