← BioTransfer GEO Dataset Finder
GEO series

ATAC-Seq of WT and Nedd4L-cKO Muscle stem cells

GSE230620 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 7 samples Submitted 2024/05/06 Platform GPL24247
Summary
Muscle stem cell quiescence is a complex and dynamic state. In this study we examined the role of the Ubiquitin Protease System in muscle stem cell function and quiescence. Using a genetic mouse model where Nedd4L is selectively deleted in myogenic cells, we characterized the effect of the loss of Nedd4L on muscle stem cells. With RNA-Seq we determined that the genetic deletion of Nedd4L resulted in the transition of the muscle stem cells out of deep quiescence and into Galert. Characterized by the upregulation of cell cycle genes and differentiation genes and loss of expression in numerous known quiescence genes. Nedd4L-cKO muscle stem cells are more prone to differentiation and fail to expand properly in vitro.
Published in
The E3 ubiquitin ligase Nedd4L preserves skeletal muscle stem cell quiescence by inhibiting their activation
Blackburn DM, Sahinyan K, Hernández-Corchado A et al. · iScience 2024 · PMID 39015146 · doi:10.1016/j.isci.2024.110241
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE230620_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 7 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA962016 and SRA study SRP434671. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 7 more — browse all 7 samples with per-sample file links →

Similar datasets

Search all mouse ChIP / ATAC / CUT&Tag datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.