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Cellular Origin and Molecular Mechanisms of Lung Metastases in Patients with Aggressive Hepatoblastoma

GSE230733 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2026/04/06 Platform GPL24676
Summary
Lung metastases are dangerous for patients with aggressive hepatoblastoma. Here we characterize a dramatic increase in cancer-associated fibroblasts and neuron-like cells that are released into the bloodstream and are found in lung metastases. Using RNAseq of fresh tumor samples taken from hepatoblastoma patients, and cells cultered from those tumors, we observe the rapid proliferation of metastasis-initiating pathways.
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Also filed as BioProject PRJNA962481 and SRA study SRP434826. Searching any of these in the dataset finder brings you back here.

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