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Therapeutic targeting of the GSK3b-CUGBP1 pathway in Myotonic Dystrophy

GSE230821 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2025/07/22 Platform GPL17021
Summary
Myotonic Dystrophy type 1 (DM1) is a neuromuscular disease associated with toxic RNA containing expanded CUG repeats. Treating mice with the GSK3 inhibitor tideglusib corrected expression of 17% of DM1-related genes. correction of the GSK3β-CUGBP1 pathway in mice expressing long CUG repeats (DMSXL model) is important not only at prenatal and postnatal stage, but also beneficial in adult mice.
Published in
Therapeutic Targeting of the GSK3β-CUGBP1 Pathway in Myotonic Dystrophy
Lutz M, Levanti M, Karns R et al. · International journal of molecular sciences 2023 · PMID 37445828 · doi:10.3390/ijms241310650
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Also filed as BioProject PRJNA962611 and SRA study SRP434927. Searching any of these in the dataset finder brings you back here.

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