Targeting NPM1 Epigenetically Promotes Post-infarction Cardiac Repair by Reprogramming Reparative Macrophage Metabolism
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 26 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 26 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Targeting NPM1 Epigenetically Promotes Postinfarction Cardiac Repair by Reprogramming Reparative Macrophage MetabolismCirculation · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE230949_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA962923 and SRA study SRP435099. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 6 replicated groups read from 26 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7247341 ko cardiac macrophage, mi-d5 ko cardiac macrophage, …
- GSM7247342 ko cardiac macrophage, mi-d5, biol rep2 ko cardiac macrophage, …
- GSM7247343 ko cardiac macrophage, mi-d5, biol rep3 ko cardiac macrophage, …
- GSM7247344 ko cardiac macrophage, mi-d5, biol rep4 ko cardiac macrophage, …
- GSM7247345 wt cardiac macrophage, mi-d5 wt cardiac macrophage, …
- GSM7247346 wt cardiac macrophage, mi-d5, biol rep2 wt cardiac macrophage, …
- GSM7247347 wt cardiac macrophage, mi-d5, biol rep3 wt cardiac macrophage, …
- GSM7247348 wt cardiac macrophage, mi-d5, biol rep4 wt cardiac macrophage, …
- GSM7247349 ko cardiac macrophage, mi-d3 ko cardiac macrophage, …
- GSM7247350 ko cardiac macrophage, mi-d3, biol rep2 ko cardiac macrophage, …
- GSM7247351 ko cardiac macrophage, mi-d3, biol rep3 ko cardiac macrophage, …
- GSM7247352 ko cardiac macrophage, mi-d3, biol rep4 ko cardiac macrophage, …
- GSM7247353 wt cardiac macrophage, mi-d3 wt cardiac macrophage, …
- GSM7247354 wt cardiac macrophage, mi-d3, biol rep2 wt cardiac macrophage, …
- GSM7247355 wt cardiac macrophage, mi-d3, biol rep3 wt cardiac macrophage, …
- GSM7247356 wt cardiac macrophage, mi-d3, biol rep4 wt cardiac macrophage, …
- GSM7933530 wt cMa, sham, npm1
- GSM7933531 wt cMa, mi, npm1
- GSM7933532 wt BMDM,UT,npm1
- GSM7933533 wt BMDMs, IL-4, npm1
- GSM7933534 wt cMa, mi, h3k4me3
- GSM7933535 ko cMa, mi, h3k4me3
- GSM7933536 wt BMDMs, IL-4, h3k4me3
- GSM7933537 ko BMDMs, IL-4, h3k4me3
- GSM7933538 wt BMDMs, IL-4, K5
- GSM7933539 ko BMDMs, IL-4, K5
- GSE306718 Macrophage Cluster of Differentiation 163 promotes post-infarction cardiac repair and preserves left ventricular function via osteopontin 37 samples shares post-infarction, macrophage, promotes
- GSE278100 Foxa1-Mediated Chromatin Remodeling and Enhancer Reprogramming Promotes Gemcitabine Resistance in Pancreatic Cancer 54 samples shares reprogramming, promotes
- GSE279042 Reprogramming of epidermal keratinocytes by PITX1 transforms the cutaneous cellular landscape and promotes wound healing [CUT&Tag] 30 samples shares reprogramming, promotes
- GSE335147 Mitochondrial profiling across macrophage states reveals inhibition of IL-4/IL-13 reprogramming by the integrated stress response 24 samples shares reprogramming, macrophage
- GSE99296 α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming 18 samples shares reprogramming, macrophage
- GSE282695 STAT3 regulates pathogen control and clearance in macrophages by reprogramming inflammation-induced microbial defense response 18 samples shares reprogramming, macrophage
- GSE261139 Tumour-derived Extracellular Vesicle and Particle Reprogramming of Interstitial Macrophages in the Lung Pre-Metastatic Niche Enhances Vascular Permeability and Metastatic Potential 16 samples shares reprogramming, macrophage
- GSE307669 Succinate-GPR91 signaling promotes cardiomyocyte metabolic reprogramming and NAD⁺ production to alleviate HFpEF 16 samples shares reprogramming, promotes
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.