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Development and validation of a microbiota signature to predict prognosis in nasopharyngeal carcinoma

GSE231572 Homo sapiens (human) RNA-seq (gene expression) 64 samples Submitted 2025/05/29 Platform GPL24676
At a glance

RNA-seq (gene expression) · human · 64 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Homo sapiens (human)
Topic
Nasopharyngeal carcinomaThis series is part of our curated briefing on it.
Samples
64 samples
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Tissue-resident microbiota signature in nasopharyngeal carcinomaMicrobiome · 2025
Summary (written by the submitters)
To investigate the risk bacteria in the regulation of NPC, we established RNA-seq in NPC tissues with high/low abundance of risk bacteria. We then performed gene expression profiling analysis using data obtained from RNA-seq of NPC tissues with high/low abundance of risk bacteria.
Published in
Tissue-resident microbiota signature in nasopharyngeal carcinoma
Tan XR, Qiao H, Li YQ et al. · Microbiome 2025 · PMID 40382629 · doi:10.1186/s40168-025-02114-w
This dataset
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE231572_RAW.tar (it can run to tens of gigabytes).

3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA966964 and SRA study SRP435778. Searching any of these in the dataset finder brings you back here.

Samples in this study

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