The application of ChIP-seq to study LSD1 and hematopoietic TF binding on enhancers upon LSD1 inhibition.
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 42 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 42 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- An autoinhibitory switch of the LSD1 disordered region controls enhancer silencingMolecular cell · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE231736_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA967458 and SRA study SRP436040. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 42 more — browse all 42 samples with per-sample file links →
- GSE244396 Binding Changes in Chromatin Factors Upon Targeted XPO1 Inhibition in T Cells 20 samples shares inhibition, binding, upon
- GSE304612 Inhibition of p300/CREBBP catalytic activity drives context-dependent transcriptional activation in AML. [ChIP-seq] 95 samples shares inhibition, chip-seq
- GSE241598 Proteasome inhibition reprograms chromatin landscape in breast cancer (ChIP-Seq) 18 samples shares inhibition, chip-seq
- GSE285943 A reference model for circulating hematopoietic stem cells with applications to diagnostics 299 samples shares hematopoietic, application
- GSE304126 CDK8 inhibition sequesters Med1 at EWS-FLI enhancers [RNA-Seq] 68 samples shares inhibition, enhancers
- GSE326276 Inhibition of inflammation and senescence with azole compound C7 enables expansion of hematopoietic stem and progenitor cells 45 samples shares hematopoietic, inhibition
- GSE287227 Transient SP140 inhibition unlocks hematopoietic stem cell fate from human pluripotent stem cells [scRNA-seq] 9 samples shares hematopoietic, inhibition
- GSE190785 Dual Targeting of FLT3 and LSD1 Disrupts the MYC Super Enhancer Complex in Acute Myeloid Leukemia. 289 samples shares lsd1
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.