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Effect of MS-275 and CXD101 on open chromatin regions of M-MDSCs [ATAC-seq]

GSE232265 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2025/02/03 Platform GPL24247
Summary
To elucidate the molecular mechanisms of HDAC1-3 inhibitors in inhibiting M-MDSCs, ATAC-seq analysis of M-MDSCs isolated from Hepa 1-6 tumor-bearing mice treated with MS-275 or CXD101 were performed.
Published in
HDAC1-3 inhibition triggers NEDD4-mediated CCR2 downregulation and attenuates immunosuppression in myeloid-derived suppressor cells
Xie Z, Shao J, Shen Z et al. · Cancer immunology, immunotherapy : CII 2025 · PMID 39891718 · doi:10.1007/s00262-024-03931-y
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Also filed as BioProject PRJNA971504 and SRA study SRP437081. Searching any of these in the dataset finder brings you back here.

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