Effect of Terpenes from Poria Cocos: Verification of Therapeutic Modes of Action for Alzheimer’s Disease using Molecular Docking, Drug-induced Transcriptomes and Diffusion Network
RNA-seq (gene expression) · human · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 18 samples: 18 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Effect of Poria cocos Terpenes: Verifying Modes of Action Using Molecular Docking, Drug-Induced Transcriptomes, and Diffusion Network AnalysesInternational journal of molecular sciences · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE232862_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA974166 and SRA study SRP438538. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 18 sample titles: 18 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7384961 BatchA_Vehicle(DMSO)_rep1 [A1-1-1]
- GSM7384962 BatchA_Vehicle(DMSO)_rep2 [A1-2-1]
- GSM7384963 BatchA_Vehicle(DMSO)_rep3 [A1-3-1]
- GSM7384964 BatchA_Wortmannin_rep1 [1-1-2]
- GSM7384965 BatchA_Wortmannin_rep2 [1-2-2]
- GSM7384966 BatchA_Wortmannin_rep3 [1-3-2]
- GSM7384967 BatchA_LY294002_rep1 [1-1-3]
- GSM7384968 BatchA_LY294002_rep2 [1-2-3]
- GSM7384969 BatchA_LY294002_rep3 [1-3-3]
- GSM7384970 BatchA_water extract of Poria Cocos (High dose)_rep1 [2-1-1]
- GSM7384971 BatchA_water extract of Poria Cocos (High dose)_rep1 [2-2-1]
- GSM7384972 BatchA_water extract of Poria Cocos (High dose)_rep1 [2-3-1]
- GSM7384973 BatchA_water extract of Poria Cocos (Medium dose)_rep1 [2-1-2]
- GSM7384974 BatchA_water extract of Poria Cocos (Medium dose)_rep2 [2-2-2]
- GSM7384975 BatchA_water extract of Poria Cocos (Medium dose)_rep3 [2-3-2]
- GSM7384976 BatchA_water extract of Poria Cocos (Low dose)_rep1 [2-1-3]
- GSM7384977 BatchA_water extract of Poria Cocos (Low dose)_rep2 [2-2-3]
- GSM7384978 BatchA_water extract of Poria Cocos (Low dose)_rep3 [2-3-3]
- GSE205672 Transcriptomes of human PBMCs and monocytes in sepsis patients 460 samples shares transcriptomes
- GSE309595 Longitudinal Analysis of Multiple Myeloma: Therapeutic Response and Immune Microenvironment Dynamics in the Context of Tumor Heterogeneity [scRNA-seq] 270 samples shares therapeutic
- GSE215274 Identification of Whole Blood Gene Expression Signature to Predict the Therapeutic Effect of Nintedanib in Idiopathic Pulmonary Fibrosis 177 samples shares therapeutic
- GSE275870 Expression profiling of primary and metastatic oral squamous cell carcinoma identifies progression-associated transcriptome changes and therapeutic vulnerabilities 108 samples shares therapeutic
- GSE294016 A macrophage-predominant, immunosuppressive immune microenvironment and subtype-specific therapeutic vulnerabilities in advanced salivary gland cancer [bulk RNA-seq] 95 samples shares therapeutic
- GSE268177 Modulating alternative splicing of MECP2: A potential therapeutic strategy for Rett syndrome 93 samples shares therapeutic
- GSE273036 Multi-Omics Analysis and Molecular Subtypes Provide Potential Therapeutic Implications in Fumarate Hydratase-deficient Renal Cell Carcinoma 93 samples shares therapeutic
- GSE252799 Zongertinib (BI01810631), an irreversible HER2 TKI, spares EGFR signaling and improves therapeutic response in preclinical models and patients with HER2-driven cancers 90 samples shares therapeutic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.