Small-molecule-induced epigenetic rejuvenation overcomes myelinogenic barriers and stimulates myelin repair
ChIP-seq / ATAC-seq (genome binding and open chromatin) · rat · 21 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Rattus norvegicus (rat)
- Samples
- 21 samples: 18 distinct titles, 2 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Small-molecule-induced epigenetic rejuvenation promotes SREBP condensation and overcomes barriers to CNS myelin regenerationCell · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE232956_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA974473 and SRA study SRP438703. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 21 sample titles: 18 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7398487 DMSO_H3K27AC
- GSM7398488 26C_H3K27AC
- GSM7398489 DMSO_H3K27me3
- GSM7398490 26C_H3K27me3
- GSM7398491 DMSO_H3K9me3
- GSM7398492 26C_H3K9me3
- GSM7398493 dmso_h3k2k27ac_X2
- GSM7398494 HDAC12i_h3k27ac_X8
- GSM7398495 rat_iOL_DMSO
- GSM7398496 rat_iOL_26c
- GSM7398497 shC_48_1_2
- GSM7398498 shC_48_2_2
- GSM7398499 shH3_1_48_1_2
- GSM7398500 shH3_1_48_3
- GSM7398501 shH3-2_48-2
- GSM7398502 shH3_2_48_3
- GSM7398503 veh1
- GSM7398504 veh2
- GSM7398505 26C_48h_1
- GSM7398506 26C_48h_2
- GSM7398507 26C_48h_3
No close match found for this topic, so these are simply the most-viewed datasets of the same kind.
- GSE268104 Single-cell multiomic comparison of mouse and rat spermatogenesis reveal gene regulatory networks conserved for over 20 million years. 70 samples
- GSE310695 Systematic Benchmarking of CUT&Tag Improves the Reliability and Reproducibility of Chromatin Analysis [Cell number] 70 samples
- GSE287856 Single-cell RNA-seq Analyses of Oocytes and Zygotes Reveal Earlier Maternal to Zygote Transition in Mice and Rats 65 samples
- GSE246744 MBNL1 regulates programmed postnatal switching between regenerative and differentiated cardiac states 54 samples
- GSE61991 Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity 35 samples
- GSE269356 Gene Signature-guided Drug Screening Identified Narciclasine as a Potential Therapeutic Drug for Renal Interstitial Fibrosis 18 samples
- GSE253257 Neural zinc finger protein Myt1 drives oligodendrocyte differentiation via repressing HDAC1-mediated histone deacetylation 13 samples
- GSE233593 Dor regulates alpha-KG metabolic pathways in mature oligodendrocytes to enhance myelination and reverse age-related remyelination decline 9 samples
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.