Gene Signature-guided Drug Screening Identified Narciclasine as a Potential Therapeutic Drug for Renal Interstitial Fibrosis
RNA-seq (gene expression) · rat · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Rattus norvegicus (rat)
- Samples
- 18 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE269356_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1121269 and SRA study SRP512519. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 6 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8313770 Con_TECs_1 Con_TECs
- GSM8313771 Con_TECs_2 Con_TECs
- GSM8313772 Con_TECs_3 Con_TECs
- GSM8313773 Tgfb_TECs_1 Tgfb_TECs
- GSM8313774 Tgfb_TECs_2 Tgfb_TECs
- GSM8313775 Tgfb_TECs_3 Tgfb_TECs
- GSM8313776 T+N_TECs_1 T+N_TECs
- GSM8313777 T+N_TECs_2 T+N_TECs
- GSM8313778 T+N_TECs_3 T+N_TECs
- GSM8313779 Con_49F_1 Con_49F
- GSM8313780 Con_49F_2 Con_49F
- GSM8313781 Con_49F_3 Con_49F
- GSM8313782 Tgfb_49F_1 Tgfb_49F
- GSM8313783 Tgfb_49F_2 Tgfb_49F
- GSM8313784 Tgfb_49F_3 Tgfb_49F
- GSM8313785 T+N_49F_1 T+N_49F
- GSM8313786 T+N_49F_2 T+N_49F
- GSM8313787 T+N_49F_3 T+N_49F
No close match found for this topic, so these are simply the most-viewed datasets of the same kind.
- GSE268104 Single-cell multiomic comparison of mouse and rat spermatogenesis reveal gene regulatory networks conserved for over 20 million years. 70 samples
- GSE310695 Systematic Benchmarking of CUT&Tag Improves the Reliability and Reproducibility of Chromatin Analysis [Cell number] 70 samples
- GSE287856 Single-cell RNA-seq Analyses of Oocytes and Zygotes Reveal Earlier Maternal to Zygote Transition in Mice and Rats 65 samples
- GSE246744 MBNL1 regulates programmed postnatal switching between regenerative and differentiated cardiac states 54 samples
- GSE61991 Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity 35 samples
- GSE232956 Small-molecule-induced epigenetic rejuvenation overcomes myelinogenic barriers and stimulates myelin repair 21 samples
- GSE253257 Neural zinc finger protein Myt1 drives oligodendrocyte differentiation via repressing HDAC1-mediated histone deacetylation 13 samples
- GSE233593 Dor regulates alpha-KG metabolic pathways in mature oligodendrocytes to enhance myelination and reverse age-related remyelination decline 9 samples
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.