STAT3 inhibition permits epigenetic reprogramming and TLR9/IRF8-driven differentiation of inv(16) acute myeloid leukemia [RNASEQ_AML_CPGDOX]
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × PBS vs 3 × CpG1668 vs 3 × Combination vs 3 × doxycyclineGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE233095_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA974911 and SRA study SRP438874. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7401358 PBS rep1 PBS
- GSM7401359 PBS rep2 PBS
- GSM7401360 PBS rep3 PBS
- GSM7401361 CpG1668_rep1 CpG1668
- GSM7401362 CpG1668_rep2 CpG1668
- GSM7401363 CpG1668_rep3 CpG1668
- GSM7401364 Combination_rep1 Combination
- GSM7401365 Combination_rep2 Combination
- GSM7401366 Combination_rep3 Combination
- GSM7401367 doxycycline_rep1 doxycycline
- GSM7401368 doxycycline_rep2 doxycycline
- GSM7401369 doxycycline_rep3 doxycycline
- GSE233096 STAT3 inhibition permits epigenetic reprogramming and TLR9/IRF8-driven differentiation of inv(16) acute myeloid leukemia [RNASEQ_AML_DECSCR] 12 samples shares stat3, tlr9, aml, reprogramming, irf8-driven, inhibition, epigenetic
- GSE233099 STAT3 inhibition permits epigenetic reprogramming and TLR9/IRF8-driven differentiation of inv(16) acute myeloid leukemia. 41 samples shares stat3, tlr9, reprogramming, irf8-driven, inhibition, epigenetic
- GSE309162 P300/CBP inhibition with gilteritinib and venetoclax targets leukemia stem cells in epigenetic mutant AML [RNA-Seq] 12 samples shares aml, inhibition, epigenetic
- GSE309163 P300/CBP inhibition with gilteritinib and venetoclax targets leukemia stem cells in epigenetic mutant AML [ChIP-Seq] 16 samples shares aml, inhibition, epigenetic
- GSE299379 KAT6A Chimeras Forms a Self-Reinforcing Epigenetic Module with NURF and MLL/COMPASS in AML [RNA-Seq] 35 samples shares aml, epigenetic
- GSE218024 STING agonism overcomes STAT3-mediated immunosuppression and adaptive resistance to PARP inhibition in ovarian cancer 24 samples shares stat3, inhibition
- GSE282695 STAT3 regulates pathogen control and clearance in macrophages by reprogramming inflammation-induced microbial defense response 18 samples shares stat3, reprogramming
- GSE249879 An epigenetic-signaling pathway interplay re-wires transcriptional program to induce therapeutic differentiation of AML 12 samples shares aml, epigenetic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.