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H3K27ac ChIP sequencing of low and high pigment B16 cells [B16_D5_LP_HP_ChIPSeq]

GSE233135 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2024/07/05 Platform GPL30172
Summary
In one of our earlier studies, we have shown that, through a pH-mediated feed-forward loop, H3K27ac selectively activates pigmentation genes and accentuates melanocyte differentiation at the population level. Here we used the B16 progressive pigmentaiton model that harbours multiple melanocyte states in the same culture. We sorted the low and high pigment cells at day 5 and investigated the differences in H3K27ac mark between the low and high pigment melanocyte sub-populations.
Published in
Distinct melanocyte subpopulations defined by stochastic expression of proliferation or maturation programs enable a rapid and sustainable pigmentation response
Aggarwal A, Nasreen A, Sharma B et al. · PLoS biology 2024 · PMID 39163475 · doi:10.1371/journal.pbio.3002776
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Also filed as BioProject PRJNA975107 and SRA study SRP438963. Searching any of these in the dataset finder brings you back here.

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