Adipocyte associated glucocorticoid signaling regulates normal fibroblast function which is lost in inflammatory arthritis
RNA-seq (gene expression) · human · 102 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 102 samples: 46 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Adipocyte associated glucocorticoid signaling regulates normal fibroblast function which is lost in inflammatory arthritisNature communications · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE233504_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA976361 and SRA study SRP523216. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 92 samples.
How we read this: 46 replicated groups read from 102 sample titles; they account for 92 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7429592 Subcutaneous adipose tissue fibroblasts, mRNA-derived cDNA
- GSM7429593 Omental adipose tissue fibroblasts, mRNA-derived cDNA
- GSM7429594 4hr_Cortisol_AMP005, bio rep 1 4hr_Cortisol_AMP005,
- GSM7429595 4hr_Cortisol_AMP005, bio rep 2 4hr_Cortisol_AMP005,
- GSM7429596 4hr_FCM_TNF_AMP005, bio rep 1 4hr_FCM_TNF_AMP005,
- GSM7429597 4hr_FCM_TNF_AMP005, bio rep 2 4hr_FCM_TNF_AMP005,
- GSM7429598 4hr_FCM_AMP005, bio rep 1 4hr_FCM_AMP005,
- GSM7429599 4hr_FCM_AMP005, bio rep 2 4hr_FCM_AMP005,
- GSM7429600 4hr_Basal_AMP005, bio rep 1 4hr_Basal_AMP005,
- GSM7429601 4hr_Basal_AMP005, bio rep 2 4hr_Basal_AMP005,
- GSM7429602 4hr_TNF_AMP005, bio rep 1 4hr_TNF_AMP005,
- GSM7429603 4hr_TNF_AMP005, bio rep 2 4hr_TNF_AMP005,
- GSM7429604 4hr_FCM_GCR_ant_AMP005, bio rep 1
- GSM7429605 4hr_Cortisol_STB-002, bio rep 1 4hr_Cortisol_STB-002,
- GSM7429606 4hr_Cortisol_STB-002, bio rep 2 4hr_Cortisol_STB-002,
- GSM7429607 4hr_FCM_TNF_STB-002, bio rep 1 4hr_FCM_TNF_STB-002,
- GSM7429608 4hr_FCM_TNF_STB-002, bio rep 2 4hr_FCM_TNF_STB-002,
- GSM7429609 4hr_FCM_STB-002, bio rep 1 4hr_FCM_STB-002,
- GSM7429610 4hr_FCM_STB-002, bio rep 2 4hr_FCM_STB-002,
- GSM7429611 4hr_Basal_STB-002, bio rep 1 4hr_Basal_STB-002,
- GSM7429612 4hr_Basal_STB-002, bio rep 2 4hr_Basal_STB-002,
- GSM7429613 4hr_TNF_STB-002, bio rep 1 4hr_TNF_STB-002,
- GSM7429614 4hr_TNF_STB-002, bio rep 2 4hr_TNF_STB-002,
- GSM7429615 4hr_FCM_GCR_ant_STB-002, bio rep 1
- GSM7429616 4hr_Cortisol_STB-009, bio rep 1 4hr_Cortisol_STB-009,
- GSM7429617 4hr_Cortisol_STB-009, bio rep 2 4hr_Cortisol_STB-009,
- GSM7429618 4hr_FCM_TNF_STB-009, bio rep 1 4hr_FCM_TNF_STB-009,
- GSM7429619 4hr_FCM_TNF_STB-009, bio rep 2 4hr_FCM_TNF_STB-009,
- GSM7429620 4hr_FCM_STB-009, bio rep 1 4hr_FCM_STB-009,
- GSM7429621 4hr_FCM_STB-009, bio rep 2 4hr_FCM_STB-009,
- GSM7429622 4hr_Basal_STB-009, bio rep 1 4hr_Basal_STB-009,
- GSM7429623 4hr_Basal_STB-009, bio rep 2 4hr_Basal_STB-009,
- GSM7429624 4hr_TNF_STB-009, bio rep 1 4hr_TNF_STB-009,
- GSM7429625 4hr_TNF_STB-009, bio rep 2 4hr_TNF_STB-009,
- GSM7429626 4hr_FCM_GCR_ant_STB-009, bio rep 1 4hr_FCM_GCR_ant_STB-009,
- GSM7429627 4hr_FCM_GCR_ant_STB-009, bio rep 2 4hr_FCM_GCR_ant_STB-009,
- GSM7429628 22hr_Cortisol_AMP005, bio rep 1 22hr_Cortisol_AMP005,
- GSM7429629 22hr_Cortisol_AMP005, bio rep 2 22hr_Cortisol_AMP005,
- GSM7429630 22hr_FCM_TNF_AMP005, bio rep 1 22hr_FCM_TNF_AMP005,
- GSM7429631 22hr_FCM_TNF_AMP005, bio rep 2 22hr_FCM_TNF_AMP005,
+ 62 more — browse all 102 samples with per-sample file links →
- GSE328951 The embryonic origins of site-specific arthritis; Bulk RNA sequencing of CD34+(Pi16+) fibroblasts stimulated with TNF and IL1b. 24 samples shares fibroblast, arthritis
- GSE269317 Reduced WNT4 expression in normal skin fibroblasts leads to ‘Dupuytren-like’ changes in the transcriptome 16 samples shares fibroblast, normal
- GSE316921 Effects of SLC2A1 knockdown in intrahepatic cholangiocarcinoma (ICC) cancer-associated fibroblasts (CAFs) on endothelial sprouting under normal and hypoxic conditions 12 samples shares fibroblast, normal
- GSE280564 Reprogramming of normal fibroblasts into ovarian cancer-associated fibroblasts via non-vesicular paracrine signaling induces an activated fibroblast phenotype 12 samples shares fibroblast, normal
- GSE294277 Integrative single cell RNA-sequencing and spatial transcriptomics uncovers distinct macrophage-fibroblast cross-talk in human hip synovium between patients with femoroacetabular impingement and osteoarthritis 22 samples shares fibroblast, arthritis
- GSE279719 Human CD14+ monocytes from early inflammatory arthritis patients before and after a 5day-and 30day-period of methotrexate treatment 72 samples shares arthritis
- GSE242941 Transcriptional profiling of skin cancer NK cells reveals the elevated glucocorticoid receptor activity alters their pro-inflammatory features. 36 samples shares glucocorticoid
- GSE296187 Interleukin-23 promotes a pro-inflammatory Th17 cell state by stabilizing RORγt and suppressing glucocorticoid receptor activity I 28 samples shares glucocorticoid
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.