Transcriptional profiling of skin cancer NK cells reveals the elevated glucocorticoid receptor activity alters their pro-inflammatory features.
Single-cell RNA-seq · human · 36 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Homo sapiens (human)
- Samples
- 36 samples: 36 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Glucocorticoid Receptor Activation Reprograms NK Cells to Drive AREG-Mediated Immunosuppression: A Pan-Cancer Role for AREGAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE242941_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1014930 and SRA study SRP459543. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 24 samples read as cases, 6 as controls.
How we read this: Read from 36 sample titles: 36 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7775340 BCC peri-tumor 1 scRNA-seq
- GSM7775341 BCC peri-tumor 2 scRNA-seq
- GSM7775342 BCC peri-tumor 3 scRNA-seq
- GSM7775343 BCC tumor 1 scRNA-seq
- GSM7775344 BCC tumor 2 scRNA-seq
- GSM7775345 BCC tumor 3 scRNA-seq
- GSM7775346 cSCC peri-tumor 1 scRNA-seq
- GSM7775347 cSCC peri-tumor 2 scRNA-seq
- GSM7775348 cSCC peri-tumor 3 scRNA-seq
- GSM7775349 cSCC tumor 1 scRNA-seq
- GSM7775350 cSCC tumor 2 scRNA-seq
- GSM7775351 cSCC tumor 3 scRNA-seq
- GSM7775352 EMPD peri-tumor 1 scRNA-seq
- GSM7775353 EMPD peri-tumor 2 scRNA-seq
- GSM7775354 EMPD peri-tumor 3 scRNA-seq
- GSM7775355 EMPD tumor 1 scRNA-seq
- GSM7775356 EMPD tumor 2 scRNA-seq
- GSM7775357 EMPD tumor 3 scRNA-seq
- GSM7775358 aMM peri-tumor 1 scRNA-seq
- GSM7775359 aMM peri-tumor 2 scRNA-seq
- GSM7775360 aMM peri-tumor 3 scRNA-seq
- GSM7775361 aMM tumor 1 scRNA-seq
- GSM7775362 aMM tumor 2 scRNA-seq
- GSM7775363 aMM tumor 3 scRNA-seq
- GSM7775364 NK control rep 1 bulk RNA-seq
- GSM7775365 NK control rep 2 bulk RNA-seq
- GSM7775366 NK control rep 3 bulk RNA-seq
- GSM7775367 NK dex rep 1 bulk RNA-seq
- GSM7775368 NK dex rep 2 bulk RNA-seq
- GSM7775369 NK dex rep 3 bulk RNA-seq
- GSM7775370 NK cytokine control 1 bulk RNA-seq
- GSM7775371 NK cytokine control 2 bulk RNA-seq
- GSM7775372 NK cytokine control 3 bulk RNA-seq
- GSM7775373 NK cytokine dex 1 bulk RNA-seq
- GSM7775374 NK cytokine dex 2 bulk RNA-seq
- GSM7775375 NK cytokine dex 3 bulk RNA-seq
- GSE296187 Interleukin-23 promotes a pro-inflammatory Th17 cell state by stabilizing RORγt and suppressing glucocorticoid receptor activity I 28 samples shares pro-inflammatory, glucocorticoid, receptor, activity
- GSE280267 Glycine Receptor Activity in β Cells Is Downregulated in Type 2 Diabetes and After High Glucose Culture 199 samples shares receptor, activity
- GSE314304 IL-11 receptor is a novel target for drug development with pharmacological activity in fibro-inflammatory disease 96 samples shares receptor, activity
- GSE278330 Systemic IL-23 blockade downregulates IL-23 receptor-expressing Type 17 T-cell subsets and upregulates regulatory gene expression in myeloid cells in human psoriasis skin 63 samples shares receptor, skin
- GSE284664 RESET: A reversible TCR-coupled antigen receptor with superior targeting sensitivity and pharmacologically controlled anti-tumor activity 62 samples shares receptor, activity
- GSE274928 The glucocorticoid receptor elicited proliferative response in human erythropoiesis is BCL11A-dependent 51 samples shares glucocorticoid, receptor
- GSE320139 The timing of antenatal glucocorticoids determines the receptor sensitivity in preterm infants 47 samples shares glucocorticoid, receptor
- GSE280810 Macrophages expressing chimeric cytokine receptors have an inflammatory phenotype and anti-tumoral activity upon IL-10 or TGFβ stimulation 30 samples shares receptor, activity
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.