GEO series
Ketogenic diet induces p53-dependent cell senescence in multiple organs
GSE233831
Mus musculus
Expression profiling by high throughput sequencing
18 samples
2024/04/12
GPL24247
Summary
Mice on two different ketogenic diets induce p53 and cellular senescence in multiple organs, including heart and kidney. This is mediated through inactivation of MDM2 by caspase-2 cleavage, leading to p53 accumulation and induction of p21. Ketogenic diet also induced pAMPK, suggesting that persistent activation leads to p53-dependent senescence.
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Paper (PMID 38758782) ↗
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