Ketogenic diet induces p53-dependent cell senescence in multiple organs
RNA-seq (gene expression) · mouse · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 18 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Ketogenic diet induces p53-dependent cellular senescence in multiple organsScience advances · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE233831_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA978062 and SRA study SRP440485. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 6 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7437605 WT heart, 21 days keto, biol rep 1 WT heart, 21 days keto,…
- GSM7437606 WT heart, 21 days keto, biol rep 2 WT heart, 21 days keto,…
- GSM7437607 WT heart, 21 days keto, biol rep 3 WT heart, 21 days keto,…
- GSM7437608 WT kidney, 21 days keto, biol rep 1 WT kidney, 21 days keto…
- GSM7437609 WT kidney, 21 days keto, biol rep 2 WT kidney, 21 days keto…
- GSM7437610 WT kidney, 21 days keto, biol rep 3 WT kidney, 21 days keto…
- GSM7437611 WT liver, 21 days keto, biol rep 1 WT liver, 21 days keto,…
- GSM7437612 WT liver, 21 days keto, biol rep 2 WT liver, 21 days keto,…
- GSM7437613 WT liver, 21 days keto, biol rep 3 WT liver, 21 days keto,…
- GSM7437614 WT heart, normal diet, biol rep 1 WT heart, normal diet, …
- GSM7437615 WT heart, normal diet, biol rep 2 WT heart, normal diet, …
- GSM7437616 WT heart, normal diet, biol rep 3 WT heart, normal diet, …
- GSM7437617 WT kidney, normal diet, biol rep 1 WT kidney, normal diet,…
- GSM7437618 WT kidney, normal diet, biol rep 2 WT kidney, normal diet,…
- GSM7437619 WT kidney, normal diet, biol rep 3 WT kidney, normal diet,…
- GSM7437620 WT liver, normal diet, biol rep 1 WT liver, normal diet, …
- GSM7437621 WT liver, normal diet, biol rep 2 WT liver, normal diet, …
- GSM7437622 WT liver, normal diet, biol rep 3 WT liver, normal diet, …
- GSE302792 SenCat: Cataloging human cell senescence through multiomic profiling of multiple senescent primary cell types 33 samples shares senescence, multiple
- GSE267196 Inter-organ transmission of hepatocellular senescence induces multi-organ dysfunction through the TGFbeta signalling pathway 20 samples shares senescence, induces
- GSE262705 Inter-organ transmission of hepatocellular senescence induces multi-organ dysfunction through the TGFβ signalling pathway. 20 samples shares senescence, induces
- GSE315211 Bulk RNA-seq of multiple organs in LmnaG609G progeria mice with inducible Δ133p53α 99 samples shares multiple, organs
- GSE283692 A ketogenic diet and voluntary exercise modify the sciatic nerve and gastrocnemius transcriptome in diet-induced obese mice 96 samples shares ketogenic, diet
- GSE290573 Doxorubicin induces the senescence-associated secretion phenotype in RAW264.7 cells 10 samples shares senescence, induces
- GSE285108 SenCat: Redefining human cell senescence through multiomic profiling of multiple senescent cell types [scRNA-seq] 9 samples shares senescence, multiple
- GSE248297 Liver RNA-seq from male C57Bl/6J on a ketogenic diet 15 samples shares ketogenic, diet
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.