Bulk RNA-seq of multiple organs in LmnaG609G progeria mice with inducible Δ133p53α

Hutchinson–Gilford progeria syndrome (HGPS) is a premature aging disorder caused by LMNA mutations that produce progerin. To investigate whether the senescence-inhibitory human p53 isoform Δ133p53α counteracts progeroid phenotypes in vivo, we generated mice carrying a Cre/loxP-inducible Δ133p53α transgene and crossed them with LmnaG609G mice. Bulk RNA-seq was performed on heart, kidney, liver, and skeletal muscle from wild-type and LmnaG609G/+ mice across five experimental groups. Transcriptomes were analyzed to identify Δ133p53α-associated gene expression programs and pathway-level changes across organs. This dataset provides a multi-organ resource to interrogate transcriptional signatures linked to Δ133p53α induction in a progeria model and support mechanistic interpretation of the associated manuscript.