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Eukaryotic Initiation factor 4B is a multi-functional RNA binding protein that regulates histone mRNAs

GSE233998 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/09/04 Platform GPL15520
Summary
In diffuse large B-cell lymphoma (DLBCL) poor outcome is associated with eIF4B-dependent stimulation of the DEAD box helicase eIF4A that unwinds RNA structures in 5’ untranslated regions (UTRs) in mRNAs that encode proteins with a role in cell proliferation. We carried out iCLIP to examine differences in RNAs bound by eIF4B in DLBCL-derived versus -control B-cells.
Published in
Eukaryotic initiation factor 4B is a multi-functional RNA binding protein that regulates histone mRNAs
Quintas A, Harvey RF, Horvilleur E et al. · Nucleic acids research 2024 · PMID 39225047 · doi:10.1093/nar/gkae767
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Also filed as BioProject PRJNA979168 and SRA study SRP440930. Searching any of these in the dataset finder brings you back here.

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