Diffuse large B-cell lymphoma: research and therapeutic landscape

12 genes recurrently implicated in diffuse large b-cell lymphoma, triaged for whether anything can actually be aimed at them. The zeros are the informative rows.

Of 12 recurrently implicated genes, 8 carry any drug at all. That is a statement about these 12 gene targets, not about the disease: Diffuse large b-cell lymphoma does have labelled therapy — 11 drugs, listed in the next section.

Dataset evidence counts studies in the 362-study ranked set whose title or abstract names the gene; the bar is scaled to MYC. Sources: Open Targets Platform and NCBI GEO, retrieved 2026-09-12. Clinical stage is the highest reached for any indication — see the per-drug indications noted in each row. Target-prioritisation reference only; not clinical or prescribing guidance.

11 drugs carry an FDA label naming diffuse large b-cell lymphoma: Axicabtagene Ciloleucel, Brentuximab Vedotin, Epcoritamab, Glofitamab, Lisocabtagene Maraleucel, Loncastuximab Tesirine, Pembrolizumab, Polatuzumab Vedotin, Rituximab, Tafasitamab, Tisagenlecleucel. Separately, 25 of the drugs returned for the genes in the table above are approved only for other diseases and reach diffuse large b-cell lymphoma through trials, not through their labels.

Every label that names diffuse large b-cell lymphoma

14 labels match indications_and_usage:"diffuse large B-cell lymphoma" OR indications_and_usage:"large B-cell lymphoma"; they collapse to 11 distinct molecules once salt forms, biosimilars and co-formulated hyaluronidase are merged. Source: openFDA drug label API (api.fda.gov/drug/label.json), retrieved 2026-09-12. Labels change; this reflects the current label text, not the approval history. Not prescribing guidance.

CD19 is the busiest cell-therapy antigen in diffuse large b-cell lymphoma: 108 registered trials, 57 still active, 2 withdrawn before enrolling anyone.

10 of 108 shown, most recently active first. Other antigens searched: CD20 (32), CD22 (7), CD79b (3), CD30 (3). Source: ClinicalTrials.gov API v2, retrieved 2026-09-12. Trials are matched on the antigen named in the title or intervention, so a trial stating only a product code is missed.

Every term below is a share of the diffuse large b-cell lymphoma literature, not a count, because the field itself grew: 2015–2018 (n=2,931) against 2021–2025 (n=5,059). A topic whose papers doubled while the field doubled has not risen.

Rising, with a real baseline

Cooling

Biggest topics now

Publication mix

Query: Lymphoma, Large B-Cell, Diffuse[MeSH Major Topic] NOT ("Hodgkin Disease"[MeSH] OR "Lymphoma, Mantle-Cell"[MeSH] OR "Burkitt Lymphoma"[MeSH] OR "Leukemia, Lymphocytic, Chronic, B-Cell"[MeSH] OR "Multiple Myeloma"[MeSH]). Terms need at least 12 papers in the recent window and, in the rising table, at least 5 in the earlier one — a term going from 1 paper to 12 is a large fold change and no evidence of anything. Ubiquitous descriptors (Humans, Animals, age bands) and the disease’s own term are dropped. Source: PubMed MeSH, retrieved 2026-09-12.

What the public sources count, and how closely each category matches this disease. The same figures for every disease on the site are on one table.

Years of life lost

2.7 years per case, 69,963 a year, from survival and age at diagnosis rather than from a death count. derived proxy What this costs to fund is in Funding.

NIH obligations naming diffuse large b-cell lymphoma, after removing the 1,234 records across all years that matched the search but are about something else. That filter is not cosmetic: without it this section reports another field’s funding as this disease’s.

NIH obligations by fiscal year

Where FY2025 money went

Text search diffuse large B-cell lymphoma over project title, terms and abstract, per fiscal year. Awards are individual funding actions; distinct projects collapse them by core project number, so a multi-year grant counts once. The most recent year may be incomplete. Source: NIH RePORTER, retrieved 2026-09-12.

What that buys

Against 69,963 years of life lost a year, FY2025 obligations are $495 per life-year — $1,322 per case. The estimate and its assumptions are in Disease burden.

Who funds it, FY2025

The total says how much. These say who from, through what kind of award, and to whom — which a dollar figure cannot.

858 human GEO series match diffuse large b-cell lymphoma. Keyword relevance cannot tell a 2,511-sample patient cohort from a six-well cell-line experiment, so this ranking scores four things GEO does not expose: how often the accession is named in full-text papers, field-normalised citation impact, clinical annotation, and cohort type.

Composition of the 362-study ranked set

Sources: NCBI GEO + Europe PMC + iCite, retrieved 2026-09-12. SubSeries are collapsed to one row per study by linked PMID. Of 858 series retrieved, 121 were dropped by the profile’s exclusion rules and 273 named the disease only in passing. The ranked set is a relevance-ranked sample, not a census, so the composition figures describe the sample only.

Each card below is a disagreement between two of the tables on this page — a drug that exists but was never tried here, a target that looks tested and was not, a gene with no drug whose product has a busy clinical programme. They are computed from the same facts as the tables, so they cannot contradict them.

This page is written to be quoted correctly by a model as much as read by a person. The same facts are available as JSON at the sibling URL below, which is what to cite.

{
  "disease": "Diffuse large B-cell lymphoma",
  "mesh": "Lymphoma, Large B-Cell, Diffuse",
  "facts": "https://usebiotransfer.org/disease/diffuse-large-b-cell-lymphoma.json",
  "methods": "https://usebiotransfer.org/methods/",
  "note": "Every figure on the page is in that JSON with its source and retrieval date. Quote from it rather than from the HTML."
}