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Senescence prostate cancer cell promotes resistance to immune checkpoint blockade through ATR activation

GSE234387 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/04/02 Platform GPL20301
Summary
Background: Checkpoint blockade immunotherapy represented by PD-1/PD-L1 or CTLA4 antibody treatment, has been of tremendous success for multiple cancers. Most patients with prostate cancer (PCa) either do not respond to CTLA4 immune checkpoint blockade or develop resistance to it, often because of low CTLA4 antigen presentation in cancer cells.
Published in
Radiotherapy-resistant prostate cancer cells escape immune checkpoint blockade through the senescence-related ataxia telangiectasia and Rad3-related protein
Shao C, Zhang Y, Li H et al. · Cancer communications (London, England) 2025 · PMID 39698847 · doi:10.1002/cac2.12636
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Also filed as BioProject PRJNA981163 and SRA study SRP441743. Searching any of these in the dataset finder brings you back here.

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