GEO series
Comprehensive analysis of mesenchymal cells reveals a deregulated TGF-B/Wnt/HOXB7 axis in patients with myelofibrosis [RNA-seq]
GSE234388
Homo sapiens
Expression profiling by high throughput sequencing
11 samples
2024/12/18
GPL15433
Summary
In this study, through a patient-sample driven transcriptomic and epigenetic description of the MF microenvironment landscape and cell-based analyses, we identify HOXB7 overexpression and more precisely a novel TGF-B-Wnt-HOXB7 pathway as associated to a pro-fibrotic and pro-osteoblastic biased differentiation of mesenchymal stromal cells (MSCs).
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Paper (PMID 39470742) ↗
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