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The difference between intraepithelial mast cells and lamina propria mast cells

GSE234414 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2024/04/15 Platform GPL23479
Summary
Type 2 immune responses are crucial for protection against helminth infections and for the maintenance of tissue homeostasis, yet the underlying mechanisms of immune activation remain incompletely understood. Here, we study the role of mast cells in type 2 immunity. While the number of lamina propria residing mast cells (termed LPMCs hereinafter) remained stable, intraepithelial mast cells (termed IEMCs hereinafter) markedly expanded during the course of type 2 responses. We uncovered a new type 2 response mechanism depending on the crosstalk between mast cells and epithelial cells, and defined the function of intraepithelial mast cells.
Published in
Intraepithelial mast cells drive gasdermin C-mediated type 2 immunity
Yang L, He H, Guo XK et al. · Immunity 2024 · PMID 38614091 · doi:10.1016/j.immuni.2024.03.017
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Also filed as BioProject PRJNA981202 and SRA study SRP441706. Searching any of these in the dataset finder brings you back here.

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