Glycation-lowering compounds inhibit ghrelin signaling to reduce food intake, lower insulin resistance, and extend lifespan.
RNA-seq (gene expression) · mouse · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 20 samples: 5 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Glycation-lowering compounds inhibit ghrelin signaling to reduce food intake, lower insulin resistance, and extend lifespanCell reports · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE234483_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA981518 and SRA study SRP441857. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 4 samples read as cases, 8 as controls.
How we read this: 5 replicated groups read from 20 sample titles; they account for 20 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7469357 acute-treated control 1 acute-treated control
- GSM7469358 acute-treated control 2 acute-treated control
- GSM7469359 acute-treated control 3 acute-treated control
- GSM7469360 acute-treated control 4 acute-treated control
- GSM7469361 acute-treated control 5 acute-treated control
- GSM7469362 acute-treated Gly-Low 1 acute-treated Gly-Low
- GSM7469363 acute-treated Gly-Low 2 acute-treated Gly-Low
- GSM7469364 acute-treated Gly-Low 3 acute-treated Gly-Low
- GSM7469365 acute-treated Gly-Low 4 acute-treated Gly-Low
- GSM7469366 old control 1 old control
- GSM7469367 old control 2 old control
- GSM7469368 old control 3 old control
- GSM7469369 old control 4 old control
- GSM7469370 old Gly-Low 1 old Gly-Low
- GSM7469371 old Gly-Low 2 old Gly-Low
- GSM7469372 old Gly-Low 3 old Gly-Low
- GSM7469373 young control 1 young control
- GSM7469374 young control 2 young control
- GSM7469375 young control 3 young control
- GSM7469376 young control 4 young control
- GSE262426 Insulin resistance alters cortical inhibitory neurons and microglia to exacerbate Alzheimer’s knock-in mouse phenotypes 16 samples shares resistance, inhibit, insulin
- GSE293819 Monitoring systemic immune responses to checkpoint inhibition in breast cancer reveals host responses and mechanisms of resistance 142 samples shares resistance, inhibit
- GSE290031 Very long-chain ceramides in skeletal muscle associate with systemic insulin resistance independent of obesity 92 samples shares resistance, insulin
- GSE277705 Integrated stress response inhibition prolongs the lifespan of a Pelizaeus-Merzbacher disease mouse model by increasing oligodendrocyte survival. 57 samples shares lifespan, inhibit
- GSE286275 Insulin Resistance Increases TNBC Aggressiveness and Brain Metastasis via Adipocyte-derived Exosomes 38 samples shares resistance, insulin
- GSE254704 Skeletal muscle cystathionine γ-lyase deficiency promotes obesity and insulin resistance and results in hyperglycemia and skeletal muscle injury upon HFD in mice 32 samples shares resistance, insulin
- GSE250238 JAK inhibitor overcomes resistance to immune checkpoint inhibitor treatment in gastric cancer peritoneal dissemination in mouse 29 samples shares resistance, inhibit
- GSE270246 Hepatic insulin resistance promotes fructose-enriched diet-induced fatty liver diseases. 22 samples shares resistance, insulin
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.