Long Non-Coding RNA MEG3 Promotes Angiogenesis by directly regulating integrin signaling impairing endothelial cell function.
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 14 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 14 samples: 14 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Control of endothelial cell function and arteriogenesis by MEG3:EZH2 epigenetic regulation of integrin expressionMolecular therapy. Nucleic acids · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE234544_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA981989 and SRA study SRP441974. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 14 sample titles: 14 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7470566 MEG3_Odd probes replicate 1, ChIRPseq [KN1_1]
- GSM7470567 MEG3_Even probes replicate 2, ChIRPseq [KN2_8]
- GSM7470568 LacZ_probes replicate 1, ChIRPseq [KN3_9]
- GSM7470569 LacZ_probes replicate 2, ChIRPseq [BR3a]
- GSM7470570 LacZ_probes replicate 3, ChIRPseq [TM_IgG]
- GSM7470571 input samples ChIRPseq [TM_input]
- GSM7470572 MEG3_Odd probes replicate 1, ChIRPseq [TM_N1]
- GSM7470573 MEG3_Even probes replicate 2, ChIRPseq [TM_N2]
- GSM7470574 Scr control EZH2 replicate 1, ChIPseq
- GSM7470575 Scr control EZH2 replicate 2, ChIPseq
- GSM7470576 Scr control EZH2 replicate 3, ChIPseq
- GSM7470577 input samples ChIPseq
- GSM7470578 MEG3 KD 10nM EZH2 replicate 1, ChIPseq
- GSM7470579 MEG3 KD 10nM EZH2 replicate 2, ChIPseq
- GSE325833 IL1R2 Identified as a Key Hub Gene Regulating Vascular Endothelial Function in Kawasaki Disease 24 samples shares endothelial, regulating
- GSE293119 Integration of Alzheimer’s GWAS, 3D genomics, and single-cell CRISPRi non-coding screen implicates causal variants in a microglial enhancer regulating TSPAN14. [RNA-Seq] 18 samples shares non-coding, regulating
- GSE318549 NAD-dependent redox control enables endothelial quiescence and vascular stabilization during angiogenesis 15 samples shares angiogenesis, endothelial
- GSE326111 Endothelial cytochrome P450 -derived cholesterol limits angiogenesis 14 samples shares angiogenesis, endothelial
- GSE281870 Disruption of PRC1 Components RING1A and RING1B Promotes Angiogenesis via Relieving BMP4 Repression [CUT&Tag] 12 samples shares angiogenesis, promotes
- GSE301613 ACSS2 modulates endothelial glycolysis in angiogenesis 9 samples shares angiogenesis, endothelial
- GSE275647 Role of Cancer-Associated Fibroblasts in Prognostic Stratification of Advanced-Stage Gastric Cancer through Interacting with Endothelial and Malignant Epithelial Cells [AGC RNA-seq] 216 samples shares endothelial
- GSE210361 Expression profiling of circular RNAs during differentiation of human pluripotent stem cells into vascular endothelial and smooth muscle cells 160 samples shares endothelial
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.