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THAP1 is a master regulator of zinc finger transcription factors guiding gastrulation of murine embryos [RNA-seq_SH]

GSE234675 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/08/01 Platform GPL24676
Summary
Gastrulation and early organogenesis are remarkable processes of early embryonic development. Our previous study showed that deletion of DYT6 gene product THAP1 leads to embryonic lethality at the stage of gastrulation and early organogenesis. However, the function of THAP1 in regulating gene expression, as well as its role in regulating embryo gastrulation and early organogenesis are not well characterized. In this study, we used different in vitro and in vivo models to characterize the function of THAP1 in regulating gene expression and in controlling embryonic development, which could help us to understand pathogenesis of THAP1-associated disorders and provide data to characterize the transcription regulation of gastrulation of murine embryo.
Published in
ZSCAN10 deficiency causes a neurodevelopmental disorder with characteristic oto-facial malformations
Laugwitz L, Cheng F, Collins SC et al. · Brain : a journal of neurology 2024 · PMID 38386308 · doi:10.1093/brain/awae058
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Also filed as BioProject PRJNA982753 and SRA study SRP442847. Searching any of these in the dataset finder brings you back here.

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