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Transcriptome analysis of cardiac specific depletion of RBPMS and RBPMS2 embryonic hearts [sch4_rnaseq]

GSE234908 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/05/05 Platform GPL19057
Summary
To investigate the function of RNA-binding protein with multiple splicing (RBPMS) family, RBPMS and RBPMS2, in heart, we establish two RBPMS/2 double knock out mutant strains using cardiomyocyte specific Cre delete strains. Xenopus laevis light chain 2 (XMLC2) promoter CRE mice (Breckenridge et al., 2007) were crossed to RBPMSflox/flox / RBPMS2flox/flox animals to generate the RBPMS/2flox/flox / XMLC2-Cre mice line. In a parallel approach, we crossbred RBPMSflox/flox / RBPMS2flox/flox mice with animals carrying alpha myosin-heavy chain (Myh6) Cre (αMyHC-Cre) (Agah et al., 1997), resulting in the RBPMS/2flox/flox / aMyHC-Cre line. RNA seq of E11.5 (XML-Cre) and E16.5 (αMyHC-Cre) embryonic hearts was performed.
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Also filed as BioProject PRJNA983729 and SRA study SRP443339. Searching any of these in the dataset finder brings you back here.

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