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Single-cell gene expression profiling of early tumorigenesis in genetically engineered mouse models of breast carcinoma

GSE234917 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/06/30 Platform GPL24247
Summary
During early tumorigenesis tumors edit their gene expression to evade immune surveillance. Because of difficulty capturing early tumors, studies of gene editing have to date mostly investigated changes in expression of candidate genes involved in activating adaptive immunity, such as those needed for antigen presentation and processing. Here we took advantage of an aggressive genetically engineered mouse model (GEMM) of breast cancer that expresses inducible oncogenic HER2 to identify tumor edited genes without bias.
Published in
Tumor editing suppresses innate and adaptive antitumor immunity and is reversed by inhibiting DNA methylation
Zhang Y, Naderi Yeganeh P, Zhang H et al. · Nature immunology 2024 · PMID 39169233 · doi:10.1038/s41590-024-01932-8
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Also filed as BioProject PRJNA983739 and SRA study SRP443356. Searching any of these in the dataset finder brings you back here.

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