GEO series

Body weight at weaning is the main predictor for diabetic phenotype in male TallyHo/JngJ mice

GSE235792 Mus musculus (mouse) RNA-seq (gene expression) 87 samples Submitted 2026/06/02 Platform GPL24247

At a glance

RNA-seq (gene expression) · mouse · 87 samples

What it is: RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism: Mus musculus (mouse)
Samples: 87 samples: 29 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
Data you can get: A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.

Summary (written by the submitters)

TallyHo/JngJ (TallyHo) mice are a polygenic mouse model for type 2 diabetes (T2D), first described in 2001 and characterized by obesity due to an increased mass of fat pads. We aimed to discover whether environmental condition(s) during early life time or epigenetic factors across generations could be responsible for the varying penetrance of the metabolic phenotype of male and female TallyHo mice. Therefore, we set up the subsequent study in which we analyzed parameters of glucose homeostasis and environmental factors of individual TallyHo mice rather than relying on group averages.

This dataset

Open GSE235792 in finder → Find more mouse RNA-seq datasets →

Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE235792_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓

3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA987632 and SRA study SRP446052. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗

Study design

29 conditions, mostly in triplicate

high blood glucose, high body weight at weani… ×4 low blood glucose, high body weight at weanin… ×4 high blood glucose, high body weight at weani… ×4 low blood glucose, high body weight at weanin… ×4 high blood glucose, high body weight at weani… ×4 high blood glucose, high body weight at weani… ×4 high blood glucose, low body weight at weanin… ×3 high body weight at weaning, female, hypothal… ×3 +21 more

Supports a between-group comparison across 87 samples.

How we read this: 29 replicated groups read from 87 sample titles; they account for 87 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

GSM7509651 high blood glucose, high body weight at weaning, male, hypothalamus, replicate 1 high blood glucose, hig…
GSM7509652 high blood glucose, high body weight at weaning, male, hypothalamus, replicate 2 high blood glucose, hig…
GSM7509653 high blood glucose, high body weight at weaning, male, hypothalamus, replicate 3 high blood glucose, hig…
GSM7509654 high blood glucose, high body weight at weaning, male, hypothalamus, replicate 4 high blood glucose, hig…
GSM7509655 high blood glucose, low body weight at weaning, male, hypothalamus, replicate 1 high blood glucose, low…
GSM7509656 high blood glucose, low body weight at weaning, male, hypothalamus, replicate 2 high blood glucose, low…
GSM7509657 high blood glucose, low body weight at weaning, male, hypothalamus, replicate 3 high blood glucose, low…
GSM7509658 high body weight at weaning, female, hypothalamus, replicate 1 high body weight at wea…
GSM7509659 high body weight at weaning, female, hypothalamus, replicate 2 high body weight at wea…
GSM7509660 high body weight at weaning, female, hypothalamus, replicate 3 high body weight at wea…
GSM7509661 low blood glucose, high body weight at weaning, male, hypothalamus, replicate 1 low blood glucose, high…
GSM7509662 low blood glucose, high body weight at weaning, male, hypothalamus, replicate 2 low blood glucose, high…
GSM7509663 low blood glucose, high body weight at weaning, male, hypothalamus, replicate 3 low blood glucose, high…
GSM7509664 low blood glucose, high body weight at weaning, male, hypothalamus, replicate 4 low blood glucose, high…
GSM7509665 low blood glucose, low body weight at weaning, male, hypothalamus, replicate 1 low blood glucose, low …
GSM7509666 low blood glucose, low body weight at weaning, male, hypothalamus, replicate 2 low blood glucose, low …
GSM7509667 low blood glucose, low body weight at weaning, male, hypothalamus, replicate 3 low blood glucose, low …
GSM7509668 low body weight at weaning, female, hypothalamus, replicate 1 low body weight at wean…
GSM7509669 low body weight at weaning, female, hypothalamus, replicate 2 low body weight at wean…
GSM7509670 low body weight at weaning, female, hypothalamus, replicate 3 low body weight at wean…
GSM7509671 high blood glucose, high body weight at weaning, male, liver, replicate 1 high blood glucose, hig…
GSM7509672 high blood glucose, high body weight at weaning, male, liver, replicate 2 high blood glucose, hig…
GSM7509673 high blood glucose, high body weight at weaning, male, liver, replicate 3 high blood glucose, hig…
GSM7509674 high blood glucose, high body weight at weaning, male, liver, replicate 4 high blood glucose, hig…
GSM7509675 high blood glucose, low body weight at weaning, male, liver, replicate 1 high blood glucose, low…
GSM7509676 high blood glucose, low body weight at weaning, male, liver, replicate 2 high blood glucose, low…
GSM7509677 high blood glucose, low body weight at weaning, male, liver, replicate 3 high blood glucose, low…
GSM7509678 high body weight at weaning, female, liver, replicate 1 high body weight at wea…
GSM7509679 high body weight at weaning, female, liver, replicate 2 high body weight at wea…
GSM7509680 low blood glucose, high body weight at weaning, male, liver, replicate 1 low blood glucose, high…
GSM7509681 low blood glucose, high body weight at weaning, male, liver, replicate 2 low blood glucose, high…
GSM7509682 low blood glucose, high body weight at weaning, male, liver, replicate 3 low blood glucose, high…
GSM7509683 low blood glucose, high body weight at weaning, male, liver, replicate 4 low blood glucose, high…
GSM7509684 low blood glucose, low body weight at weaning, male, liver, replicate 1 low blood glucose, low …
GSM7509685 low blood glucose, low body weight at weaning, male, liver, replicate 2 low blood glucose, low …
GSM7509686 low blood glucose, low body weight at weaning, male, liver, replicate 3 low blood glucose, low …
GSM7509687 low body weight at weaning, female, liver, replicate 1 low body weight at wean…
GSM7509688 low body weight at weaning, female, liver, replicate 2 low body weight at wean…
GSM7509689 high blood glucose, high body weight at weaning, male, muscle, replicate 1 high blood glucose, hig…
GSM7509690 high blood glucose, high body weight at weaning, male, muscle, replicate 2 high blood glucose, hig…

+ 47 more — browse all 87 samples with per-sample file links →

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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.