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RET overexpression leads to increased brain metastatic competency in luminal breast cancer

GSE235886 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/06/25 Platform GPL28038
Summary
In the present study we aimed to explore the role of tyrosine kinase receptor, RET, in promoting breast cancer brain metastasis. Using patient-derived brain metastatic models, we found RET significantly enriched in brain metastasis originating from estrogen receptor positive breast cancer where it played a key role in promoting cancer cell adhesion, survival, and outgrowth in the brain.
Published in
RET overexpression leads to increased brain metastatic competency in luminal breast cancer
Jagust P, Powell AM, Ola M et al. · Journal of the National Cancer Institute 2024 · PMID 38852945 · doi:10.1093/jnci/djae091
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Also filed as BioProject PRJNA987983 and SRA study SRP446160. Searching any of these in the dataset finder brings you back here.

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