A non-canonical repressor function of JUN restrains YAP activity and suppresses YAP-dependent liver cancer growth [CUT&RUN]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 64 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 64 samples: 24 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- A non-canonical repressor function of JUN restrains YAP activity and liver cancer growthThe EMBO journal · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE235960_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA988088 and SRA study SRP446131. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 64 samples.
How we read this: 24 replicated groups read from 64 sample titles; they account for 64 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7512367 10A_ev_etoh, YAP1, rep1 10A_ev_etoh, YAP1,
- GSM7512368 10A_ev_etoh, JUN, rep1 10A_ev_etoh, JUN,
- GSM7512369 10A_ev_etoh, cFOS, rep1 10A_ev_etoh, cFOS,
- GSM7512370 10A_ev_etoh, NCOR1, rep1 10A_ev_etoh, NCOR1,
- GSM7512371 10A_ev_etoh, ARID1A, rep1 10A_ev_etoh, ARID1A,
- GSM7512372 10A_ev_etoh, IgG, rep1 10A_ev_etoh, IgG,
- GSM7512373 10A_ev_dox, YAP1, rep1 10A_ev_dox, YAP1,
- GSM7512374 10A_ev_dox, JUN, rep1 10A_ev_dox, JUN,
- GSM7512375 10A_ev_dox, cFOS, rep1 10A_ev_dox, cFOS,
- GSM7512376 10A_ev_dox, NCOR1, rep1 10A_ev_dox, NCOR1,
- GSM7512377 10A_ev_dox, ARID1A, rep1 10A_ev_dox, ARID1A,
- GSM7512378 10A_ev_dox, IgG, rep1 10A_ev_dox, IgG,
- GSM7512379 10A_JUNoe_etoh, YAP1, rep1 10A_JUNoe_etoh, YAP1,
- GSM7512380 10A_JUNoe_etoh, JUN, rep1 10A_JUNoe_etoh, JUN,
- GSM7512381 10A_JUNoe_etoh, cFOS, rep1 10A_JUNoe_etoh, cFOS,
- GSM7512382 10A_JUNoe_etoh, NCOR1, rep1 10A_JUNoe_etoh, NCOR1,
- GSM7512383 10A_JUNoe_etoh, ARID1A, rep1 10A_JUNoe_etoh, ARID1A,
- GSM7512384 10A_JUNoe_etoh, IgG, rep1 10A_JUNoe_etoh, IgG,
- GSM7512385 10A_ev_etoh, YAP1, rep2 10A_ev_etoh, YAP1,
- GSM7512386 10A_ev_etoh, JUN, rep2 10A_ev_etoh, JUN,
- GSM7512387 10A_ev_etoh, cFOS, rep2 10A_ev_etoh, cFOS,
- GSM7512388 10A_ev_etoh, NCOR1, rep2 10A_ev_etoh, NCOR1,
- GSM7512389 10A_ev_etoh, ARID1A, rep2 10A_ev_etoh, ARID1A,
- GSM7512390 10A_ev_etoh, IgG, rep2 10A_ev_etoh, IgG,
- GSM7512391 10A_ev_dox, YAP1, rep2 10A_ev_dox, YAP1,
- GSM7512392 10A_ev_dox, JUN, rep2 10A_ev_dox, JUN,
- GSM7512393 10A_ev_dox, cFOS, rep2 10A_ev_dox, cFOS,
- GSM7512394 10A_ev_dox, NCOR1, rep2 10A_ev_dox, NCOR1,
- GSM7512395 10A_ev_dox, ARID1A, rep2 10A_ev_dox, ARID1A,
- GSM7512396 10A_ev_dox, IgG, rep2 10A_ev_dox, IgG,
- GSM7512397 10A_JUNoe_etoh, YAP1, rep2 10A_JUNoe_etoh, YAP1,
- GSM7512398 10A_JUNoe_etoh, JUN, rep2 10A_JUNoe_etoh, JUN,
- GSM7512399 10A_JUNoe_etoh, cFOS, rep2 10A_JUNoe_etoh, cFOS,
- GSM7512400 10A_JUNoe_etoh, NCOR1, rep2 10A_JUNoe_etoh, NCOR1,
- GSM7512401 10A_JUNoe_etoh, ARID1A, rep2 10A_JUNoe_etoh, ARID1A,
- GSM7512402 10A_JUNoe_etoh, IgG, rep2 10A_JUNoe_etoh, IgG,
- GSM8240953 10A_ev_etoh, YAP1, rep3 10A_ev_etoh, YAP1,
- GSM8240954 10A_ev_etoh, JUN, rep3 10A_ev_etoh, JUN,
- GSM8240955 10A_ev_etoh, FOS, rep3 10A_ev_etoh, FOS,
- GSM8240956 10A_ev_etoh, NCOR1, rep3 10A_ev_etoh, NCOR1,
+ 24 more — browse all 64 samples with per-sample file links →
- GSE270125 Divergent medulloblastoma chromatin states disclose KDM2B as a selective dependency [CUT&Run] 169 samples shares cut, run
- GSE270503 Epigenetic heterogeneity and state-specific transcriptional programs determine differential drug response in osteosarcoma [Cut&Run] 56 samples shares cut, run
- GSE303343 A unified network systems approach uncovers a core program underlying T follicular helper cell differentiation [CUT&RUN] 48 samples shares cut, run
- GSE287902 BPTF regulstes androgen receptor activity by enhancing chromatin accessibility and stabilizing the AR-FOXA1 interaction [Cut&Run] 40 samples shares cut, run
- GSE278910 Pooled CRISPR screens with joint single-nucleus chromatin accessibility and transcriptome profiling [CUT&RUN] 30 samples shares cut, run
- GSE301512 Chromatin topology dynamics of dexamethasone-treated trabecular meshwork identifies 78 causal genes for intraocular pressure and primary open angle glaucoma [CUT&Run] 30 samples shares cut, run
- GSE253893 PAX translocations remodel mitochondrial metabolism through altered leucine usage in rhabdomyosarcoma [Cut&Run] 28 samples shares cut, run
- GSE260732 Impact of c-JUN deficiency on thalamus development in mice and human neural models [ATACseq, RNAseq, CUT&Tag] 23 samples shares jun, cut
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.